DISC2 (gene)

disrupted in schizophrenia 2 (non-protein coding)
Identifiers
Symbols	DISC2; DISC1OS; NCRNA00015
External IDs	OMIM: 606271 GeneCards: DISC2 Gene
Gene Ontology
Orthologs
Species	Human	Mouse
Entrez	27184	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	NR_002227	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a

In molecular biology, disrupted in schizophrenia 2 (non-protein coding), also known as DISC2, is long non-coding RNA. In humans it is located on chromosome 1, at the breakpoint associated with the chromosomal translocation found in Schizophrenia.^[1] It is antisense to the DISC1 gene and may regulate the expression of DISC1.^[1][2] DISC2 may also contribute to other psychiatric disorders.^[2][3]

See also

• Long noncoding RNA

References

1. ^ ^{a b} Millar, J. K.; Wilson-Annan, J. C.; Anderson, S.; Christie, S.; Taylor, M. S.; Semple, C. A.; Devon, R. S.; St Clair, D. M. et al. (2000). "Disruption of two novel genes by a translocation co-segregating with schizophrenia". Human molecular genetics 9 (9): 1415–1423. PMID 10814723.  edit
2. ^ ^{a b} Millar, J. K.; James, R.; Brandon, N. J.; Thomson, P. A. (2004). "DISC1 and DISC2: Discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of medicine 36 (5): 367–378. PMID 15478311.  edit
3. ^ Hodgkinson, C. A.; Goldman, D.; Jaeger, J.; Persaud, S.; Kane, J. M.; Lipsky, R. H.; Malhotra, A. K. (2004). "Disrupted in Schizophrenia 1 (DISC1): Association with Schizophrenia, Schizoaffective Disorder, and Bipolar Disorder". The American Journal of Human Genetics 75 (5): 862–872. doi:10.1086/425586. PMC 1182115. PMID 15386212. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1182115.  edit

Further reading

• Kato, T. (2001). "Molecular genetics of bipolar disorder". Neuroscience research 40 (2): 105–113. PMID 11377748.  edit
• Blackwood, D. H.; Fordyce, A.; Walker, M. T.; St Clair, D. M.; Porteous, D. J.; Muir, W. J. (2001). "Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family". American journal of human genetics 69 (2): 428–433. PMC 1235314. PMID 11443544. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1235314.  edit
• Devon, R. S.; Anderson, S.; Teague, P. W.; Burgess, P.; Kipari, T. M.; Semple, C. A.; Millar, J. K.; Muir, W. J. et al. (2001). "Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder". Psychiatric genetics 11 (2): 71–78. PMID 11525420.  edit
• Taylor, M. S.; Devon, R. S.; Millar, J. K.; Porteous, D. J. (2003). "Evolutionary constraints on the Disrupted in Schizophrenia locus". Genomics 81 (1): 67–77. PMID 12573262.  edit
• Millar, J. K.; James, R.; Brandon, N. J.; Thomson, P. A. (2004). "DISC1 and DISC2: Discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of medicine 36 (5): 367–378. PMID 15478311.  edit
• Farmer, A.; Elkin, A.; McGuffin, P. (2007). "The genetics of bipolar affective disorder". Current Opinion in Psychiatry 20 (1): 8–12. doi:10.1097/YCO.0b013e3280117722. PMID 17143075.  edit
• Chubb, J. E.; Bradshaw, N. J.; Soares, D. C.; Porteous, D. J.; Millar, J. K. (2007). "The DISC locus in psychiatric illness". Molecular Psychiatry 13 (1): 36–64. doi:10.1038/sj.mp.4002106. PMID 17912248.  edit
• Williams, J. M.; Beck, T. F.; Pearson, D. M.; Proud, M. B.; Cheung, S. W.; Scott, D. A. (2009). "A 1q42 Deletion Involving DISC1, DISC2, and TSNAX in an Autism Spectrum Disorder". American Journal of Medical Genetics Part A 149A (8): 1758–1762. doi:10.1002/ajmg.a.32941. PMC 2909829. PMID 19606485. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2909829.  edit