Cytochrome c assembly protein family

Cytochrome C assembly protein
Identifiers
Symbol	Cytochrom_C_asm
Pfam	PF01578
Pfam clan	CL0328
InterPro	IPR002541
TCDB	9.B.14
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

In molecular biology, the cytochrome c assembly protein family includes various proteins involved in cytochrome c assembly from mitochondria and bacteria. Members of this family include: CycK from Rhizobium leguminosarum,^[1] CcmC from Escherichia coli and Paracoccus denitrificans,^[2][3] and orf240 from Triticum aestivum (Wheat) mitochondria.^[4] The members of this family are probably integral membrane proteins with six predicted transmembrane helices that may comprise the membrane component of an ABC (ATP binding cassette) transporter complex. This transporter may be necessary for transport of some component needed for cytochrome c assembly. One member, R. leguminosarum CycK, contains a putative haem-binding motif.^[1] Wheat orf240 also contains a putative haem-binding motif and is a proposed ABC transporter with c-type haem as its proposed substrate.^[4] However it seems unlikely that all members of this family transport haem or c-type apocytochromes because P. denitrificans CcmC transports neither.^[3]

References

1. ^ ^{a b} Delgado MJ, Yeoman KH, Wu G, Vargas C, Davies AE, Poole RK, Johnston AW, Downie JA (September 1995). "Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum". J. Bacteriol. 177 (17): 4927–34. PMC 177267. PMID 7665469. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=177267. 
2. ^ Thony-Meyer L, Fischer F, Künzler P, Ritz D, Hennecke H (August 1995). "Escherichia coli genes required for cytochrome c maturation". J. Bacteriol. 177 (15): 4321–6. PMC 177179. PMID 7635817. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=177179. 
3. ^ ^{a b} Page MD, Pearce DA, Norris HA, Ferguson SJ (February 1997). "The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of their products to form a haem or apo- c-type cytochrome transporter". Microbiology (Reading, Engl.) 143 ( Pt 2): 563–76. PMID 9043133. 
4. ^ ^{a b} Bonnard G, Grienenberger JM (January 1995). "A gene proposed to encode a transmembrane domain of an ABC transporter is expressed in wheat mitochondria". Mol. Gen. Genet. 246 (1): 91–9. PMID 7529870. 

This article includes text from the public domain Pfam and InterPro IPR002541