Cyrus Chothia

Cyrus Chothia
Cyrus Chothia
Institutions Laboratory of Molecular Biology
Alma mater University College London
Doctoral advisor Peter J. Pauling (son of Linus Pauling)
Doctoral students Mark Bender Gerstein,[1] Julian Gough,[2] Alex Bateman,[3] Steven E. Brenner
Other notable students Arthur M. Lesk (postdoc)
Notable awards Fellow of the Royal Society (2000)[4]

Cyrus Chothia FRS is an emeritus scientist at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB)[5][6] and emeritus fellow of Wolfson College, Cambridge.[4][7]

After his Ph.D. research under Peter Pauling[8] at University College London, Chothia worked in the LMB for three years. He then worked for Michael Levitt at the Weizmann Institute of Science [9][10] followed by two years with Joel Janin at the Institut Pasteur in Paris.[11]

In 1976 Chothia returned to England to work at University College London and the LMB. With Arthur M. Lesk[12][13] he showed that proteins adapt to mutations by changes in structure.

In 1992 he proposed that most proteins are built of domains that come from a small number of families. He collaborated with Alexey Murzin, Steven E. Brenner and Tim Hubbard to create the Structural Classification of Proteins (SCOP) database,[14][15] a periodic table for all known protein structures. With Julian Gough[2] to create the SUPERFAMILY database[16] which uses Hidden Markov models to identify protein sequences that are related to those of known structures.

References

  1. ^ Gerstein, M.; Chothia, C. (1991). "Analysis of protein loop closure. Two types of hinges produce one motion in lactate dehydrogenase". Journal of molecular biology 220 (1): 133–149. doi:10.1016/0022-2836(91)90387-L. PMID 2067013.  edit
  2. ^ a b "Dr. Julian Gough's home page at the University of Bristol". http://www.cs.bris.ac.uk/~gough/. Retrieved 2011-07-26. 
  3. ^ "Dr Alex Bateman - Wellcome Trust Sanger Institute". http://www.sanger.ac.uk/research/faculty/abateman/. Retrieved 2011-07-26. 
  4. ^ a b "Wolfson College: Emeritus Fellow Dr Cyrus Chothia MA MSc FRS". http://www.wolfson.cam.ac.uk/fellows/emeritus/open/?i=8972. Retrieved 2011-07-26. 
  5. ^ "Cyrus Chothia: The protein origins of biological complexity, LMB Emeritus". http://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus-scientists/cyruschothia. Retrieved 2011-07-26. 
  6. ^ http://www.mrc-lmb.cam.ac.uk/tcb/chothia_research.html Structural genomics and protein structure
  7. ^ http://www.biomedexperts.com/Profile.bme/238495/NN Cyrus Chothia profile on BiomedExperts
  8. ^ Chothia, C.; Pauling, P. (1969). "On the conformations of hallucinogenic molecules and their correlation". Proceedings of the National Academy of Sciences of the United States of America 63 (4): 1063–1070. doi:10.1073/pnas.63.4.1063. PMC 223427. PMID 4311249. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=223427.  edit
  9. ^ Chothia, C.; Levitt, M.; Richardson, D. (1977). "Structure of proteins: Packing of alpha-helices and pleated sheets". Proceedings of the National Academy of Sciences of the United States of America 74 (10): 4130–4134. doi:10.1073/pnas.74.10.4130. PMC 431889. PMID 270659. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=431889.  edit
  10. ^ Levitt, M.; Chothia, C. (1976). "Structural patterns in globular proteins". Nature 261 (5561): 552–558. Bibcode 1976Natur.261..552L. doi:10.1038/261552a0. PMID 934293.  edit
  11. ^ Sweet, R.; Wright, H.; Janin, J.; Chothia, C.; Blow, D. (1974). "Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6-A resolution". Biochemistry 13 (20): 4212–4228. doi:10.1021/bi00717a024. PMID 4472048.  edit
  12. ^ Lesk, A.; Chothia, C. (1980). "How different amino acid sequences determine similar protein structures: The structure and evolutionary dynamics of the globins". Journal of molecular biology 136 (3): 225–270. doi:10.1016/0022-2836(80)90373-3. PMID 7373651.  edit
  13. ^ Lesk, A.; Chothia, C. (1980). "Solvent accessibility, protein surfaces, and protein folding". Biophysical Journal 32 (1): 35–47. Bibcode 1980BpJ....32...35L. doi:10.1016/S0006-3495(80)84914-9. PMC 1327253. PMID 7248454. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1327253.  edit
  14. ^ Hubbard, T.; Murzin, A.; Brenner, S.; Chothia, C. (1997). "SCOP: A structural classification of proteins database". Nucleic Acids Research 25 (1): 236–239. doi:10.1093/nar/25.1.236. PMC 146380. PMID 9016544. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146380.  edit
  15. ^ http://www.bbsrc.ac.uk/pa/grants/PersonDetails.aspx?Personid=23905 BBSRC Investigator details: Dr Cyrus Chothia
  16. ^ Gough, J.; Chothia, C. (2002). "SUPERFAMILY: HMMs representing all proteins of known structure. SCOP sequence searches, alignments and genome assignments". Nucleic Acids Research 30 (1): 268–272. doi:10.1093/nar/30.1.268. PMC 99153. PMID 11752312. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99153.  edit

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