Chymotrypsin-C

Chymotrypsin C (caldecrin)
Identifiers
Symbols	CTRC; CLCR; ELA4
External IDs	OMIM: 601405 MGI: 1923951 HomoloGene: 21422 GeneCards: CTRC Gene
EC number	3.4.21.2
Gene Ontology Molecular function • serine-type endopeptidase activity • peptidase activity Biological process • proteolysis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11330	76701
Ensembl	ENSG00000162438	ENSMUSG00000062478
UniProt	Q99895	Q3SYP2
RefSeq (mRNA)	NM_007272	NM_001033875.2
RefSeq (protein)	NP_009203	NP_001029047.1
Location (UCSC)	Chr 1: 15.76 – 15.78 Mb	Chr 4: 141.39 – 141.4 Mb
PubMed search	[1]	[2]

Chymotrypsin C, also known as caldecrin or elastase 4 is an enzyme that in humans is encoded by the CTRC gene.^[1][2]

Function

Chymotrypsin C is a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity.^[1]

References

1. ^ ^{a b} "Entrez Gene: chymotrypsin C (caldecrin)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11330. 
2. ^ Tomomura A, Akiyama M, Itoh H, Yoshino I, Tomomura M, Nishii Y, Noikura T, Saheki T (May 1996). "Molecular cloning and expression of human caldecrin". FEBS Lett. 386 (1): 26–8. doi:10.1016/0014-5793(96)00377-8. PMID 8635596. 

Further reading

• . 
• Freeman TC, Davies R, Calam J (1990). "Interactions of pancreatic secretory trypsin inhibitor in small intestinal juice: its hydrolysis and protection by intraluminal factors.". Clin. Chim. Acta 195 (1-2): 27–39. doi:10.1016/0009-8981(90)90191-T. PMID 2093478. 
• Masson E, Chen JM, Scotet V, et al. (2008). "Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis.". Hum. Genet. 123 (1): 83–91. doi:10.1007/s00439-007-0459-3. PMID 18172691. 
• Rosendahl J, Witt H, Szmola R, et al. (2008). "Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis.". Nat. Genet. 40 (1): 78–82. doi:10.1038/ng.2007.44. PMC 2650829. PMID 18059268. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2650829. 
• Kitahara K, Kawa S, Katsuyama Y, et al. (2008). "Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.". Dis. Markers 25 (3): 175–80. PMID 19096130. 
• Stavridi ES, O'Malley K, Lukacs CM, et al. (1996). "Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.". Biochemistry 35 (33): 10608–15. doi:10.1021/bi9605806. PMID 8718849. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
• Chang MC, Chang YT, Wei SC, et al. (2009). "Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan.". Pancreatology 9 (3): 287–92. doi:10.1159/000199437. PMID 19407484. 
• Yoshino-Yasuda I, Kobayashi K, Akiyama M, et al. (1998). "Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene.". J. Biochem. 123 (3): 546–54. PMID 9538241. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Harris WR, Malencik DA, Johnson CM, et al. (1990). "Purification and characterization of catalytic fragments of phosphorylase kinase gamma subunit missing a calmodulin-binding domain.". J. Biol. Chem. 265 (20): 11740–5. PMID 2365696. 
• Derikx MH, Szmola R, te Morsche RH, et al. (2009). "Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants.". Eur J Gastroenterol Hepatol 21 (8): 889–94. doi:10.1097/MEG.0b013e32832183cf. PMID 19404200. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Szmola R, Sahin-Tóth M (2007). "Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y.". Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11227–32. doi:10.1073/pnas.0703714104. PMC 2040881. PMID 17592142. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2040881. 
• Brecher AS, Yang MP (1998). "Acetaldehyde inhibits chymotrypsin and serum anti-chymotrypsin activity.". J. Investig. Med. 46 (4): 146–52. PMID 9635374.