Cherry-red spot

Cherry-red spot

A cherry-red spot is a finding in the macula of the eye in a variety of lipid storage disorders and in central retinal artery occlusion.[1] It describes the appearance of a small circular choroid shape as seen through the fovea centralis. [2] Its appearance is due to a relative transparency of the macula; storage disorders cause the accumulation of storage material within the cell layers of the retina, however, the macula, which is relatively devoid of cellular layers, does not build up this material, and thus allows the eye to see through the macula to the red choroid below. [3]

The sign was first described by Warren Tay, founding member of the British Ophthalmological Society, in 1881, with reference to a patient with Tay-Sachs disease.

The cherry red spot is seen in central retinal artery occlusion, appearing several hours after the blockage of the retinal artery occurs.[4] The cherry red spot is seen because the macula receives its blood supply from the choroid artery while the surrounding retina is pale due to retinal artery infarction.[5] It is also seen in several other conditions, classically Tay-Sachs Disease, but also in Niemann-Pick Disease, Sandhoff disease, and mucolipidosis.

Contents

Differential Diagnosis of Cherry Red Spot at Macula

  1. Metabolic Storage Diseases:
    1. Mucopolysaccharidosis
    2. Hurler's disease
    3. Tay-Sachs disease
    4. MPS VII
    5. Farber's disease
    6. GM1 gangliosidoses
    7. Juvenileeroid
    8. Niemann Pick's disease
    9. Sandoff's disease
    10. Shprintzen-Goldberg syndrome
    11. Lysosomal Storage Diseases
  2. Congenital Developmental Diseases : Amaurosis, congenital, Leber's
  3. Hereditary/ Familial:
    1. Hallervorden Spatz disease
    2. leukodystrophy, Krabbe's
  4. Degenerative: Metachromatic leukodystrophy
  5. Vascular: central retinal artery occlusion
  6. Drugs:
    1. Quinine toxicity
    2. Dapsone toxicity
  7. Poisoning:
    1. Carbon monoxide
    2. Methanol

See also

  • lipid storage disease

References

  1. ^ General Practice Notebook
  2. ^ Medical Dictionary
  3. ^ Suvarna JC, Hajela SA. Cherry-red spot. J Postgrad Med 2008;54:54-7.
  4. ^ Rakel, Robert E., Textbook of Family Medicine, 7th ed, Chapter 53
  5. ^ ""USMLE First AID 2010 page 417

External links



Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • cherry-red spot — a red circular area (the choroid) surrounded by gray white retina, seen through the fovea centralis of the eye in Tay Sachs disease and several other neurodegenerative storage diseases. It is caused by accumulation of sphingolipids in retinal… …   Medical dictionary

  • spot — 1. SYN: macula. 2. To lose a slight amount of blood through the vagina. acoustic spots macula of utricle, macula of saccule. Bitot spots small, circumscribed, lusterless, grayish white, foamy, greasy, triangular deposits on the bulbar …   Medical dictionary

  • Red Guitars — The Red Guitars were a English indie rock band active from 1982 to 1986. Based in Hull, the Red Guitars first single Good Technology was a minor hit, selling 60,000 copies. Their third single Marimba Jive reached number one on the UK Indie Chart… …   Wikipedia

  • Tay spot (sign) — (ta) [Warren Tay, English physician, 1843–1927] cherry red spot; see under spot …   Medical dictionary

  • Cherry Lips — For the Japanese animation studio see Cherry Lips (company). Cherry Lips Single by Garbage from the album Beautiful G …   Wikipedia

  • cherry angioma — see angioma * * * a bright red to purple, smooth, dome shaped lesion representing a telangiectatic vascular disturbance, usually found on the trunk or proximal end of a limb; these are common in elderly persons, but the onset may be earlier in… …   Medical dictionary

  • Tay spot — cherry red s …   Medical dictionary

  • Black Cherry (Kumi Koda album) — Infobox Album | Name = Black Cherry Type = Studio album Artist = Kumi Koda Lower caption = CD only Cover Released = December 20, 2006 Recorded = Japan Genre = J Pop Length = Label = Rhythm Zone RZCD 45506/B C (Japan, CD+2DVD) RZCD 45507/B (Japan …   Wikipedia

  • Tay sign — cherry red spot …   Medical dictionary

  • CRSM — cherry red spot myoclonus …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”