Bakuchiol

Bakuchiol
Bakuchiol
Chemical structure of bakuchiol
IUPAC name
4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol
Other names
(+)-Bakuchiol
Identifiers
CAS number 10309-37-2 N=
PubChem 5468522
ChemSpider 4579217 YesY
UNII OT12HJU3AR YesY
ChEMBL CHEMBL262344 YesY
Jmol-3D images Image 1
Properties
Molecular formula C18H24OO
Molar mass 256.38 g/mol
Exact mass 256.182715 u
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Bakuchiol is a natural phenol and a meroterpene (a chemical compound having a partial terpenoid structure) found in Psoralea corylifolia[1][2][3] and in Otholobium pubescens.[4]

One study in rats suggested that bakuchiol and ethanol extracts of the Chinese medicinal plant Psoralea corylifolia could protect against bone loss.[5] Bakuchiol isolated from P. corylifolia has shown activity against numerous Grampositive and Gram-negative oral pathogens. It was able to inhibit the growth of Streptococcus mutans under a range of sucrose concentrations, pH values and in the presence of organic acids in a temperature-dependent manner and also inhibited the growth of cells adhered to a glass surface.[6]

References

  1. ^ Biosynthesis of bakuchiol, a meroterpene from Psoralea corylifolia. Asok Banerji and Chintalwar G. J., Phytochemistry, 1983, vol. 22, no9, pp. 1945-1947, INIST:9311490
  2. ^ Amyloglucosidase Catalyzed Syntheses of Bakuchiol Glycosides in Supercritical Carbon Dioxide. Balaraman Manohar, Soundar Divakar and Kadimi Udaya Sankar, Bull. Korean Chem. Soc. 2009, Vol. 30, No. 8, pp. 1760-1766, INIST:22343814
  3. ^ Bakuchiol: A Hepatoprotective Compound of Psoralea corylifolia on Tacrine-Induced Cytotoxicity in Hep G2 Cells. Hyun Cho, Jung-Yang Jun, Eun-Kyoung Song, Ki-Hong Kang, Hum-Young Baek, Yong-Suk Ko and Youn-Chul Kim, Planta Med., 2001, 67(8), pp. 750-751, doi:10.1055/s-2001-18347
  4. ^ Isolation and antihyperglycemic activity of bakuchiol from Otholobium pubescens (fabaceae), a peruvian medicinal plant used for the treatment of diabetes. Krenisky J. M., Luo J., Reed M. J. and Carney J. R., Biological & pharmaceutical bulletin, 1999, vol. 22, no10, pp. 1137-1140, INIST:1198639
  5. ^ Ethanol extract of Psoralea corylifolia L. and its main constituent, bakuchiol, reduce bone loss in ovariectomised Sprague-Dawley rats. Lim SH, Ha TY, Kim SR, Ahn J, Park HJ and Kim S, Br J Nutr., 2009 Apr, 101(7), pp. 1031-1039
  6. ^ Dental Caries and Medicinal Plants –An Overview. Parimala Devi B. and Ramasubramaniaraj R., Journal of Pharmacy Research, 2009, 2(11), pp. 1669-1675 http://jpronline.info/article/view/906/708

External links

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