Dishevelled
Dishevelled specific domain
PBB Protein DVL1 image.jpg
Solution structure of the mouse Dvl-1 DEP domain based on the PDB 1fsh coordinates.
Identifiers
Symbol Dishevelled
Pfam PF02377
InterPro IPR003351
PROSITE PDOC50841

Dishevelled (Dsh) is a family of proteins involved in canonical and non-canonical Wnt signalling pathways. Dsh is a cytoplasmic phosphoprotein that acts directly downstream of frizzled receptors.[1] It takes its name from its initial discovery in flies, where a mutation in the dishevelled gene was observed to cause improper orientation of body and wing hairs.[2]

Dishevelled plays important roles in both the embryo and the adult, ranging from cellular differentiation and cell polarity to social behavior.[3]

Members

There are three human genes that encode dishevelled proteins:[4]

Overview of signal transduction pathways involved in apoptosis.

References

  1. ^ Penton A, Wodarz A, Nusse R (June 2002). "A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin". Genetics 161 (2): 747–62. PMC 1462152. PMID 12072470. http://www.genetics.org/cgi/pmidlookup?view=long&pmid=12072470. 
  2. ^ Wallingford J; Habas R (2005). "The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity". Development 132 (20): 4421–4436. http://dev.biologists.org/content/132/20/4421.full. Retrieved 31 August 2011. 
  3. ^ Wallingford JB, Habas R (October 2005). "The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity". Development 132 (20): 4421–36. doi:10.1242/dev.02068. PMID 16192308. 
  4. ^ Lee YN, Gao Y, Wang HY (February 2008). "Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3". Cell. Signal. 20 (2): 443–52. doi:10.1016/j.cellsig.2007.11.005. PMC 2233603. PMID 18093802. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2233603. 

External links