Transfer RNA-like structures
- Transfer RNA-like structures
Transfer RNA-like structures (tRNA-like structures) are RNA sequences, which have a similar tertiary structure to tRNA, but contain a pseudoknot close to the 3' end[cite journal |author=Dreher TW |title=Role of tRNA-like structures in controlling plant virus replication |journal=Virus Res. |volume= |issue= |pages= |year=2008 |month=July |pmid=18638511 |doi=10.1016/j.virusres.2008.06.010 |url=] . ]The presence of tRNA-like structures has been demonstrated in many plant virus RNA genomes. These tRNA-like structures are linked to regulation of plant virus replication[cite journal |author=Dreher TW |title=Role of tRNA-like structures in controlling plant virus replication |journal=Virus Res. |volume= |issue= |pages= |year=2008 |month=July |pmid=18638511 |doi=10.1016/j.virusres.2008.06.010 |url=] .]tRNA-like structures mimic some tRNA function, such as aminoacylation. There are three aminoacylation specificities, valine, histidine and tyrosine. For example, valine binds to the tRNA-like structure of the turnip yellow mosaic virus genome whilst tyrosine binds to the tRNA-like structure of the barley stripe mosaic virus genome[cite journal |author=Mans RM, Pleij CW, Bosch L |title=tRNA-like structures. Structure, function and evolutionary significance |journal=Eur. J. Biochem. |volume=201 |issue=2 |pages=303–24 |year=1991 |month=October |pmid=1935928 |doi= |url=http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0014-2956&date=1991&volume=201&issue=2&spage=303] . tRNA-like structures which lack the 3' termini lack complete or partial tRNA mimicry.]tRNA-like structures are required for RNA encapsulation and increase RNA stability. They also act as 3'-translational enhancers[cite journal |author=Matsuda D, Dreher TW |title=The tRNA-like structure of Turnip yellow mosaic virus RNA is a 3'-translational enhancer |journal=Virology |volume=321 |issue=1 |pages=36–46 |year=2004 |month=March |pmid=15033563 |doi=10.1016/j.virol.2003.10.023 |url=] and regulators of minus strand sythesis][cite journal |author=Dreher TW |title=Role of tRNA-like structures in controlling plant virus replication |journal=Virus Res. |volume= |issue= |pages= |year=2008 |month=July |pmid=18638511 |doi=10.1016/j.virusres.2008.06.010 |url=] .] References
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