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Mesangial proliferative glomerulonephritis

Mesangial proliferative glomerulonephritis
Mesangial proliferative glomerulonephritis
Classification and external resources

Renal corpuscle. Intraglomerular mesangium is #5b.
ICD-10 N00.3-N08.3
DiseasesDB 31877

Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the mesangium.[1]

There is some evidence that interleukin-10 may inhibit it in an animal model.[2]

It is classified as type II lupus nephritis by the World Health Organization (WHO).

Mesangial cells in the renal glomerulus use endocytosis to take up and degrade circulating immunoglobulin. This normal process stimulates mesangial cell proliferation and matrix deposition. Therefore, during times of elevated circulating immunoglobulin (i.e., lupus and IgA nephropathy) one would expect to see an increased number of mesangial cells and matrix in the glomerulus. This is characteristic of nephritic syndromes.

References

  1. ^ "Definition: mesangial proliferative glomerulonephritis from Online Medical Dictionary". http://cancerweb.ncl.ac.uk/cgi-bin/omd?mesangial+proliferative+glomerulonephritis. 
  2. ^ Kitching AR, Katerelos M, Mudge SJ, Tipping PG, Power DA, Holdsworth SR (April 2002). "Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis". Clin. Exp. Immunol. 128 (1): 36–43. doi:10.1046/j.1365-2249.2002.01793.x. PMC 1906377. PMID 11982588. http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0009-9104&date=2002&volume=128&issue=1&spage=36. 
v · d · eLupus nephritis
Class I (Minimal mesangial glomerulonephritis) · Class II (Mesangial proliferative lupus nephritis) · Class III (Focal proliferative nephritis)  · Class IV (Diffuse proliferative nephritis) · Class V (Membranous nephritis) · Class VI (Glomerulosclerosis)
v · d · eUrinary system · Pathology · Urologic disease / Uropathy (N00–N39, 580–599)
Abdominal
Glomerulopathy/
glomerulitis/
(glomerulonephritis+
glomerulonephrosis)
Primarily
nephrotic
.3 Mesangial proliferative · .4 Endocapillary proliferative .5/.6 Membranoproliferative/mesangiocapillary
By condition
Primarily
nephritic,
.7 RPG
Type III RPG/Pauci-immune
Tubulopathy/
tubulitis
RTA (RTA 2) · Fanconi syndrome
Any/all
Any/all
General syndromes
Renal failure (Acute renal failure, Chronic renal failure) · Uremic pericarditis · Uremia
Other
Ureter
Pelvic
Urethra
Any/all

M: URI

anat/phys/devp/cell

noco/acba/cong/tumr, sysi/epon, urte

proc/itvp, drug (G4B), blte, urte



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