HLA-B52

HLA-B52

Alleles

There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B*5201 is the most common, but others have a large regional abundance.{|border="0" cellspacing="0" cellpadding="1" align="left" style="text-align:center; margin-right: 3em; border:1px #ffeebb solid; background:#f8f6f8; "

Disease

In ulcerative colitis

HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan.cite journal |author=Sugimura K, Asakura H, Mizuki N, "et al" |title=Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis |journal=Hum. Immunol. |volume=36 |issue=2 |pages=112–8 |year=1993 |month=February |pmid=8096500 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/0198-8859(93)90113-F] cite journal |author=Nomura E, Kinouchi Y, Negoro K, "et al" |title=Mapping of a disease susceptibility locus in chromosome 6p in Japanese patients with ulcerative colitis |journal=Genes Immun. |volume=5 |issue=6 |pages=477–83 |year=2004 |month=September |pmid=15215890 |doi=10.1038/sj.gene.6364114 |url=] This form of disease is frequently found with Takayasu's arteritis.cite journal |author=Oyanagi H, Ishihata R, Ishikawa H, "et al" |title=Ulcerative colitis associated with Takayasu's disease |journal=Intern. Med. |volume=33 |issue=2 |pages=127–9 |year=1994 |month=February |pmid=7912572 |doi= |url=http://joi.jlc.jst.go.jp/JST.Journalarchive/internalmedicine1992/33.127?from=PubMed] cite journal |author=Sato R, Sato Y, Ishikawa H, "et al" |title=Takayasu's disease associated with ulcerative colitis |journal=Intern. Med. |volume=33 |issue=12 |pages=759–63 |year=1994 |month=December |pmid=7718956 |doi= |url=http://joi.jlc.jst.go.jp/JST.Journalarchive/internalmedicine1992/33.759?from=PubMed]

In Takayasu's arteritis

Takayasu's arteritis appears to have an independent link to B52 associated disease.cite journal |author=Kimura A, Kitamura H, Date Y, Numano F |title=Comprehensive analysis of HLA genes in Takayasu arteritis in Japan |journal=Int. J. Cardiol. |volume=54 Suppl |issue= |pages=S61–9 |year=1996 |month=August |pmid=9119528 |doi= |url=] cite journal |author=Yoshida M, Kimura A, Katsuragi K, Numano F, Sasazuki T |title=DNA typing of HLA-B gene in Takayasu's arteritis |journal=Tissue Antigens |volume=42 |issue=2 |pages=87–90 |year=1993 |month=August |pmid=7903491 |doi= |url=] The association with B*5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance.cite journal |author=Kitamura H, Kobayashi Y, Kimura A, Numano F |title=Association of clinical manifestations with HLA-B alleles in Takayasu arteritis |journal=Int. J. Cardiol. |volume=66 Suppl 1 |issue= |pages=S121–6 |year=1998 |month=October |pmid=9951811 |doi= |url=]

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • HLA-B5 — (B5) is an HLA B serotype. B5 is a serotype that recognizes the B51 and B52 serotypes.cite journal | author = Marsh SG, Albert ED, Bodmer WF, et al | title = Nomenclature for factors of the HLA system, 2004 | journal = Tissue Antigens | volume =… …   Wikipedia

  • HLA-A1 — monoisoform isoformgroup = HLA A1 polymer type = MHC Class I, A cell surface antigen image source = Rendering of PDB2|1W72: α (A*0101 gene product), β2 microglobulin, and MAGE 1 peptide. protein type = transmembrane receptor/ligand structure = αβ …   Wikipedia

  • HLA-A68 — SerotypeA normal locus = A type = 68 image PDB2|2hla showing A*6801 (cyan) and Beta 2 microglobulin (rose). There is no bound peptide in this image. allelegroup = 68 alleles = 1 common alleles = 3 rare alleles = 1 alias = A28 broad = 28 | sister1 …   Wikipedia

  • B-52 (disambiguation) — B 52 may refer to: * Bundesstraße 52, a German road * B 52 Stratofortress, a strategic bomber aircraft designed by Boeing * B 52 hairstyle, a type of beehive, named after the aircraft * The B 52 s, a rock band, named after the hairstyle named… …   Wikipedia

  • split antigen — noun In the testing of cell surface antigens, an antigen that has a more refined or specific cell surface reaction relative to a broad antigen.(Example: HLA B51 and HLA B52 are split antigens of HLA B5)<ref name>Okimoto K, Juji T, Ishiba S …   Wiktionary

  • broad antigen — noun In the testing of cell surface antigens, a serological specificity that is poor or broad relative to other specificities and can be defined as 2 or more split antigens.(Example: HLA B51 and HLA B52 are split antigens of the HLA B5 broad… …   Wiktionary

  • History and naming of human leukocyte antigens — In these instances, the A1/A2, A2/A3, A1/A3 are matched, decreasing the probability of a rejection because many are linked to a given haplotype. Occasionally the recombinant A1 Cw7 B7(rare), B7 becomes the alloantigen in a recipient with A1 Cw7… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”