Conessine

Conessine
Other names N,N-Dimethyl-con-5-enin-3-amine
Identifiers
CAS number	546-06-5 Y
PubChem	2860
MeSH	Conessine
ChEMBL	CHEMBL191703 N
Jmol-3D images	Image 1
SMILES C[C@H]1[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3CC=C5[C@@]4(CC[C@@H](C5)N(C)C)C)CN1C
Properties
Molecular formula	C24H40N2
Molar mass	356.5878
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Conessine is a steroid alkaloid found in a number of plant species from the Apocynaceae family, including Holarrhena floribunda,^[1] Holarrhena antidysenterica^[2] and Funtumia elastica,^[3] several of which are used in traditional herbal medicine as a treatment for amoebic dysentery.^[4] It acts as a histamine antagonist, selective for the H₃ subtype.^[5]

References

1. ^ Duez P, Chamart S, Lejoly J, Hanocq M, Zeba B, Sawadogo M, Guissou P, Molle L. Changes in conessine in stem bark of Holarrhena floribunda in Burkina Faso. Annales Pharmaceutiques Francaises (French). 1987;45(4):307-13. PMID 3445993
2. ^ Kumar N, Singh B, Bhandari P, Gupta AP, Kaul VK. Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL. Chemical and Pharmaceutical Bulletin (Tokyo). 2007 Jun;55(6):912-4. PMID 17541193
3. ^ Zirihi GN, Grellier P, Guédé-Guina F, Bodo B, Mambu L. Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorganic and Medicinal Chemistry Letters. 2005 May 16;15(10):2637-40. PMID 15863333
4. ^ Garg S, Bhutani KK. Chromatographic analysis of Kutajarista--an ayurvedic polyherbal formulation. Phytochemical Analysis. 2008 Jul;19(4):323-8. PMID 18197597
5. ^ Santora VJ, Covel JA, Hayashi R, Hofilena BJ, Ibarra JB, Pulley MD, Weinhouse MI, Sengupta D, Duffield JJ, Semple G, Webb RR, Sage C, Ren A, Pereira G, Knudsen J, Edwards JE, Suarez M, Frazer J, Thomsen W, Hauser E, Whelan K, Grottick AJ. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorganic and Medicinal Chemistry Letters. 2008 Feb 15;18(4):1490-4. PMID 18194865

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.v · http://www.flickr.com/photos/lokenrc/5833058127/ কুরচি (= Kurchi in Bangla), कुतज (= Kutaja in Sanskrit), bitterer Oleander (auf Deutsch), Holarrhena antidysenterica Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Fernando Volio Jiménez Mauro Fernández Acuña Look at other dictionaries: conessine — ● conessine nom féminin Alcaloïde stéroïdique, extrait de diverses apocynacées, et possédant une action spécifique contre les amibes et les flagellés. conessine [kɔnesin] n. f. ÉTYM. 1887, cit.; de conessi, nom de plante. ❖ ♦ Chim., méd.… …   Encyclopédie Universelle conessine — Wrightine Wright ine, n. (Chem.) A rare alkaloid found in the bark of an East Indian apocynaceous tree ({Wrightia antidysenterica}), and extracted as a bitter white crystalline substance. It was formerly used as a remedy for diarrh[oe]a. Called… …   The Collaborative International Dictionary of English conessine — kəˈne(ˌ)sēn, nesə̇n noun ( s) Etymology: International Scientific Vocabulary conessi (bark) + ine : a very bitter poisonous crystalline alkaloid C24H40N2 obtained from certain tropical trees of the family Apocynaceae (especially Holarrhena… …   Useful english dictionary conessine — noun A steroid alkaloid found in a number of plant species of the Apocynaceae family, sometimes used in herbal medicine as a treatment for amoebic dysentery …   Wiktionary conessine — A steroid alkaloid derived from Holarrhena antidysenterica (conessi); a yellow astringent, used in the treatment of amebic dysentery and vaginal trichomoniasis. SYN: neriine, wrightine …   Medical dictionary conessine — co·nes·sine …   English syllables neriine — Wrightine Wright ine, n. (Chem.) A rare alkaloid found in the bark of an East Indian apocynaceous tree ({Wrightia antidysenterica}), and extracted as a bitter white crystalline substance. It was formerly used as a remedy for diarrh[oe]a. Called… …   The Collaborative International Dictionary of English Wrightia antidysenterica — Wrightine Wright ine, n. (Chem.) A rare alkaloid found in the bark of an East Indian apocynaceous tree ({Wrightia antidysenterica}), and extracted as a bitter white crystalline substance. It was formerly used as a remedy for diarrh[oe]a. Called… …   The Collaborative International Dictionary of English Wrightine — Wright ine, n. (Chem.) A rare alkaloid found in the bark of an East Indian apocynaceous tree ({Wrightia antidysenterica}), and extracted as a bitter white crystalline substance. It was formerly used as a remedy for diarrh[oe]a. Called also… …   The Collaborative International Dictionary of English Alkaloid — This article is about the chemical compounds alkaloids. For the pharmaceutical company in the Republic of Macedonia see Alkaloid (company).Alkaloids are naturally occurring chemical compounds containing basic nitrogen atoms.… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”