Talaporfin

Talaporfin

Systematic (IUPAC) name
N-{[(2S,3S)-7-carboxy-3-(2-carboxyethyl)-12-ethyl-2,8,13,18-tetramethyl-17-vinyl-2,3-dihydroporphyrin-5-yl]acetyl}-L-aspartic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	IV
Identifiers
CAS number	110230-98-3 220201-34-3 (sodium salt)
ATC code	None
PubChem	CID 5486799
UNII	P4ROX5ELT2 Y
Chemical data
Formula	C38H41N5O9
Mol. mass	711.76 g/mol
SMILES	eMolecules & PubChem
Y(what is this?)  (verify)

Talaporfin (INN, also known as aspartyl chlorin, mono-L-aspartyl chlorine e6, NPe6, or LS11) is a photosensitizer used in photodynamic therapy (PDT).

It absorbs red light at 664nm normally provided by a laser tuned to this wavelength.^[1]

It was approved in Japan (in 2004) for PDT of lung cancer and marketed as Laserphyrin.^[2]

It is trademarked as Aptocine by Light Sciences Oncology.^[3]

References

1. ^ http://journals.lww.com/jto/Fulltext/2006/06000/Photodynamic_Therapy__PDT__for_Lung_Cancers.18.aspx "Photodynamic Therapy (PDT) for Lung Cancers" 2006
2. ^ http://meeting.ascopubs.org/cgi/content/abstract/24/18_suppl/7229 "Photodynamic therapy using Laserphyrin for centrally located early stage lung cancer" 2006
3. ^ http://www.lsoncology.com/aptocine

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