Tetrazolylglycine

Tetrazolylglycine

Chembox new
ImageFile=Tetrazolylglycine.pngImageSize=
IUPACName=2-amino-2-(2H-tetrazol-5-yl)acetic acid
OtherNames=
Section1= Chembox Identifiers
CASNo=138199-51-6
PubChem=126383
SMILES=C1(=NNN=N1)C(C(=O)O)N

Section2= Chembox Properties
Formula=C3H5N5O2
MolarMass=143.104
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=

Section3= Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

Tetrazolylglycine (Tet-Gly, LY-285,265) is a potent and selective NMDA receptor agonist, stimulating the NMDA receptor with higher potency than either glutamate or NMDA. [Lunn WH, Schoepp DD, Calligaro DO, Vasileff RT, Heinz LJ, Salhoff CR, O'Malley PJ. DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy. "Journal of Medicinal Chemistry". 1992 Nov 27;35(24):4608-12. PMID 1361579] It is a potent convulsant and excitotoxin and is used in scientific research. [Schoepp DD, Smith CL, Lodge D, Millar JD, Leander JD, Sacaan AI, Lunn WH. D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. "European Journal of Pharmacology". 1991 Oct 15;203(2):237-43. PMID 1686860] [Schoepp DD, Lunn WH, Salhoff CR, McDonald JW. The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin. "European Journal of Pharmacology". 1994 Jan 3;270(1):67-72. PMID 8157082]

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • Phencyclidine — Systematic (IUPAC) name …   Wikipedia

  • Toluene — IUPAC name …   Wikipedia

  • Nitrous oxide — N2O redirects here. For other uses, see N2O (disambiguation). Laughing gas redirects here. For other uses, see Laughing gas (disambiguation). Not to be confused with nitric oxide (formula NO) or nitrogen dioxide (formula NO2). For other uses, see …   Wikipedia

  • Domoic acid — Identifiers CAS number 14277 97 5 …   Wikipedia

  • Glutamic acid — Glutamic acid …   Wikipedia

  • Amitriptyline — Systematic (IUPAC) name …   Wikipedia

  • DCKA — IUPAC name 5,7 dichloro 4 oxo 1H quinoline 2 carboxylic acid …   Wikipedia

  • Aniracetam — Systematic (IUPAC) name 1 [(4 methoxybenzoyl)] 2 pyrrolidinone …   Wikipedia

  • Amantadine — Systematic (IUPAC) name adamantan 1 amine …   Wikipedia

  • Dizocilpine — Systematic (IUPAC) name (+) 5 methyl 10,11 dihydro 5H dibenzo[a,d]cyclohepten 5,10 imine maleate Clinical data Pregnancy cat …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”