Tetrazole

Tetrazole

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ImageFileL1=Tetrazole numbering.pngImageSizeL1=100px
ImageFileR1=Tetrazole3d.pngImageSizeR1=100px
IUPACName=1H-Tetrazole
OtherNames=
Section1= Chembox Identifiers
CASNo=288-94-8
PubChem=
SMILES=C1NNN [NH] 1

Section2= Chembox Properties
Formula=CH2N4
MolarMass=70.05 g/mol
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=
pKa = 4.90 [Phys. Chem. Chem. Phys., 2002, 4, 4314-4318]
pKb =

Section3= Chembox Hazards
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Section8 = Chembox Related
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Tetrazoles are a class of synthetic organic heterocyclic compound, consisting of a 5-member ring of four nitrogen and one carbon atom (plus hydrogens). The simplest is tetrazole itself, CN4H2. They are unknown in nature. There are several pharmaceutical agents which are tetrazoles, but they are generally undesirable due to safety concerns for process-scale synthesis; tetrazoles are usually explosive. However, tetrazoles can act as a pharmacophore for the carboxylate group, increasing their utility. Angiotensin II receptor blockers, in particular, often contain tetrazoles, such as Losartan and Candesartan. A well-known tetrazole is MTT, which is a di"m"ethyl "t"hiazolyl diphenyl "t"etrazolium salt. This tetrazole is used in the MTT assay to quantify the respiratory activity of live cells in cell culture, although it generally kills the cells in the process.

Other tetrazoles are used for their explosive or combustive properties, such as tetrazole itself and 5-aminotetrazole, which are sometimes used as a component of gas generators in automobile airbags. They produce high-temperature, non-toxic reaction products, and have a high burn rate and (relative) stability, all of which are desirable properties.

Tetrazole was first prepared by the reaction of anhydrous hydrazoic acid and hydrogen cyanide under pressure.

References

External links


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Look at other dictionaries:

  • Tetrazole — Tet*raz ole, n. [Tetrazo + ole.] (Org. Chem.) A crystalline acid substance, {CH2N4}, which may be regarded as pyrrol in which nitrogen atoms replace three {CH} groups; also, any of various derivatives of the same. [Webster 1913 Suppl.] …   The Collaborative International Dictionary of English

  • tétrazole — ● tétrazole nom masculin Composé hétérocyclique CH2N4, formé par l action de l acide cyanhydrique sur l acide azothydrique, dont certains dérivés sont employés comme médicaments ou comme colorants …   Encyclopédie Universelle

  • tetrazole — tetrazolas statusas T sritis chemija apibrėžtis Penkianaris heterociklinis junginys. formulė CH₂N₄ atitikmenys: angl. tetrazole rus. тетразол …   Chemijos terminų aiškinamasis žodynas

  • tetrazole — noun A five membered heterocycle having one carbon atom, four nitrogen atoms and two double bonds …   Wiktionary

  • tetrazole — The compound CN4H2 with the structure of tetrazolium. * * * tet·ra·zole te trə .zōl n a crystalline acidic compound CH2N4 containing a five membered ring composed of one carbon and four nitrogen atoms also any of various derivatives of this… …   Medical dictionary

  • tetrazole — tet·ra·zole …   English syllables

  • tetrazole — ˈte.trəˌzōl noun ( s) Etymology: International Scientific Vocabulary tetraz + ole : a crystalline acidic parent compound CH2N4 containing a ring composed of one carbon atom and four nitrogen atoms; also : any of various derivatives of this… …   Useful english dictionary

  • CH — Tetrazole Tet*raz ole, n. [Tetrazo + ole.] (Org. Chem.) A crystalline acid substance, {CH2N4}, which may be regarded as pyrrol in which nitrogen atoms replace three {CH} groups; also, any of various derivatives of the same. [Webster 1913 Suppl.] …   The Collaborative International Dictionary of English

  • CH2N4 — Tetrazole Tet*raz ole, n. [Tetrazo + ole.] (Org. Chem.) A crystalline acid substance, {CH2N4}, which may be regarded as pyrrol in which nitrogen atoms replace three {CH} groups; also, any of various derivatives of the same. [Webster 1913 Suppl.] …   The Collaborative International Dictionary of English

  • Tetrazol — Strukturformel Allgemeines Name Tetrazol Andere Namen …   Deutsch Wikipedia

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