cachectin
Protein produced by macrophages that is responsible for the wasting (cachexia) associated with some tumours. Now known to be identical to tumour necrosis factor (TNF). Has three 17 kD subunits, all derived from a single highly-conserved gene.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • cachectin — /keuh kek tin/, n. Biochem., Immunol. a protein that is released by activated macrophages as an immune system defense and, when the defense is overwhelmed, is a cause of cachexia or toxic shock: in humans, identical with tumor necrosis factor. [… …   Universalium

  • cachectin — noun The polypeptide hormone cachexin or tumor necrosis factor …   Wiktionary

  • cachectin — A polypeptide cytokine, produced by endotoxin activated macrophages, which has the ability to modulate adipocyte metabolism, lyse tumor cells in vitro, and induce hemorrhagic necrosis of certain transplantable tumors in vivo. SYN: tumor …   Medical dictionary

  • Cachectin — Ca|chec|tin [griech. kachexía = schlechter Körperzustand; ↑ in (3)], das; s, e: svw. ↑ Tumor Nekrose Faktor …   Universal-Lexikon

  • cachectin — /keuh kek tin/, n. Biochem., Immunol. a protein that is released by activated macrophages as an immune system defense and, when the defense is overwhelmed, is a cause of cachexia or toxic shock: in humans, identical with tumor necrosis factor. [… …   Useful english dictionary

  • Tumor necrosis factor-alpha — Tumor necrosis factor (TNF, cachexin or cachectin and formally known as tumor necrosis factor alpha ) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF causes… …   Wikipedia

  • Tumor necrosis factors — TNF(Tumour Necrosis Factor) family [[Image: Model of TNF alpha, produced by M. musculus, based on PDB structure 2TNF (1.4Å Resolution). Different colors represent different monomers. Baeyens, KJ et al. (1999) …   Wikipedia

  • Bruce A. Beutler — Bruce A. Beutler, an immunologist and geneticist, was born in Chicago, Illinois on 29 December, 1957, and is a US citizen. He is a Professor and Chairman of the Department of Genetics at The Scripps Research Institute, in La Jolla, California,… …   Wikipedia

  • Kevin J. Tracey — (b. 10 December 1957, Fort Wayne, IN, USA) is Director of The Feinstein Institute for Medical Research and Professor and President of the Elmezzi Graduate School of Molecular Medicine in Manhasset, NY. Although trained as a neurosurgeon, he is an …   Wikipedia

  • Wasting — could also mean unefficient and/or uneffective consumption. See waste. In medical circles, wasting refers to the process by which a debilitating disease causes muscle and fat tissue to waste away. Wasting is sometimes referred to as acute… …   Wikipedia

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