bride of sevenless
(= boss)
In Drosophila eye development, the ligand for the sevenless tyrosine kinase receptor. Boss is expressed by the central R8 cell. It is unusual as a ligand for a tyrosine receptor kinase in that it is on the surface of another cell and has, in addition to a large extracellular domain, seven transmembrane segments and a C-terminal cytoplasmic tail.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Sevenless — Drosophila gene that is required for development of the R7 cell in each ommatidium in the eye. Gene product is a receptor tyrosine kinase, related to the insulin receptor. Ligand is the product of the bride of sevenless gene. In the downstream… …   Dictionary of molecular biology

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  • Class C GPCR — 7 transmembrane receptor (metabotropic glutamate family) Identifiers Symbol 7tm 3 Pfam PF00003 InterPro …   Wikipedia

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