voltage-sensitive calcium channels


voltage-sensitive calcium channels
(= VSCC)
A variety of voltage-sensitive calcium channels are known and on the basis of electrophysiological and pharmacological criteria are grouped into six classes. The general function is to allow calcium influx into the cell as a result of membrane depolarization. The majority (L-type, N-type, P-type and Q-type channels require substantial depolarization and are sometimes collectively known as high voltage-activated types. The R-type channels activate after moderate depolarization and the T-type channel opens at relatively negative potentials.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

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  • calcium channel — Membrane channel that is specific for calcium. Probably the best characterized is the voltage gated channel of the sarcoplasmic reticulum which is ryanodine sensitive. See voltage sensitive calcium channels …   Dictionary of molecular biology

  • Voltage-gated ion channel — Voltage gated ion channels are a class of transmembrane ion channels that are activated by changes in electrical potential difference near the channel; these types of ion channels are especially critical in neurons, but are common in many types… …   Wikipedia

  • Voltage-gated potassium channel — Ion channel (eukariotic) Potassium channel, structure in a membrane like environment. Calculated hydrocarbon boundaries of the lipid bilayer are indicated by red and blue dots. Identifiers Symbol Ion trans …   Wikipedia

  • L-type channels — A class of voltage sensitive calcium channels. L type channels are found in neurons, neuroendocrine cells, smooth, cardiac and striated muscle, are involved in neurotransmitter release at some synapses and inactivate relatively slowly. They are… …   Dictionary of molecular biology

  • Q-type channels — A class of voltage sensitive calcium channels. May be identical or very similar to P type channels. Inhibited by neurotransmitters that act through G protein coupled receptors, high concentrations of w conotoxin and w agatoxin …   Dictionary of molecular biology

  • N-type channels — Lackie A class of voltage sensitive calcium channels. Restricted to neurons and neuroendocrine cells where they are involved in regulation of neurotransmitter or neurohormone release. Require substantial depolarization to become activated and… …   Dictionary of molecular biology

  • P-type channels — A class of voltage sensitive calcium channels. Found in various neurons but particularly in Purkinje cells of the cerebellum (hence the name). Involved in induction of long term depression. Require substantial depolarization to activate and… …   Dictionary of molecular biology

  • R-type channels — A class of neuronal voltage sensitive calcium channels that are unaffected by dihydropyridines, phenylalkylamines and conotoxins. Thought to carry much of the current, stimulated by glutamate release in response to ischaemia, that induces… …   Dictionary of molecular biology

  • T-type channels — A class of voltage sensitive calcium channels that open transiently in response to relatively small depolarizations of the neuronal membrane. May have a role in repetitive firing. No selective inhibitors are known …   Dictionary of molecular biology


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