(= vascular endothelial growth factor; vascular permeability factor; VPF)Growth factor of the PDGF family that stimulates mitosis in vascular endothelium, angiogenesis, and also increases permeability of endothelial monolayers. Tissue-specific splice variants (VEGF121, VEGF165, VEGF-C) are found, VEGF165 having heparin-binding activity which VEGF121 lacks. VEGF121 only binds to flk-1. Functional form is a dimer (or heterodimer of splice variants) that binds to flt-1 (VEGF-R1), flt-4 (VEGF- R3, binds only VEGF-C) or flk-1 (VEGF-R2/KDR) receptor tyrosine kinases. Can form heterodimer with placental growth factor (PLGF). See Tie and flt.
Dictionary of molecular biology. 2004.