tumour suppressor
(= antioncogene; cancer susceptibility gene)
A gene that encodes a product that normally negatively regulates the cell cycle, and that must be mutated or otherwise inactivated before a cell can proceed to rapid division. Examples: p53, RB (retinoblastoma), WT-1 (Wilms&’ tumour), DCC (deleted in colonic carcinoma), NF-1 (neurofibrosarcoma) and APC (adenomatous polyposis coli).

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • tumour suppressor gene — ▪ pathology also called  Anti oncogene,         any of a class of genes that are normally involved in regulating cell growth but that may become cancer causing when damaged. Tumour suppressor genes encode for proteins that are involved in… …   Universalium

  • Malignant rhabdoid tumour — Classification and external resources ICD O: 8963/3 OMIM 609322 MeSH …   Wikipedia

  • Wilms' tumour — Childhood kidney tumour. Like retinoblastoma, both sporadic and inherited forms occur. Believed to be caused by development of homozygosity for a deletion mutation of the tip of the short arm of chromosome 11, which is presumed to contain a… …   Dictionary of molecular biology

  • Tumor suppressor gene — A tumor suppressor gene, or antioncogene is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with… …   Wikipedia

  • ARF tumor suppressor — The ARF tumor suppressor is a protein that is transcribed from an alternate reading frame of the INK4a/ARF locus (CDKN2A).[1] ARF is induced in response to sustained mitogenic stimulation, such as aberrant growth signaling from MYC and Ras… …   Wikipedia

  • Von Hippel-Lindau tumor suppressor — The Von Hippel Lindau tumor suppressor protein is encoded by the VHL gene and when inactivated is associated with Von Hippel Lindau disease. PBB Summary section title = summary text = Von Hippel Lindau syndrome (VHL) is a dominantly inherited… …   Wikipedia

  • Rb — Tumour suppressor gene encoding a nuclear protein that, if inactivated, enormously raises the chances of development of cancer, classically retinoblastoma, but also other sarcomas and carcinomas …   Dictionary of molecular biology

  • Deleted in Colorectal Cancer — Deleted in colorectal carcinoma Rendering based on PDB 2ED7 …   Wikipedia

  • p53 — For the band and album of the same name, see P53 (band) and P53 (album). Tumor protein p53 PDB rendering based on 1TUP …   Wikipedia

  • genetic disease, human — Introduction       any of the diseases and disorders that are caused by mutations in one or more genes (gene).       With the increasing ability to control infectious and nutritional diseases in developed countries, there has come the realization …   Universalium

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”