transforming growth factor
Proteins secreted by transformed cells that can stimulate growth of normal cells. Unfortunate misnomer, since they induce aspects of transformed phenotype, such as growth in semi-solid agar, but do not actually transform. TGF- a, a 50 amino acid polypeptide originally isolated from viral-transformed rodent cells, contains EGF-like domain and binds to EGF receptor. Stimulates growth of microvascular endothelial cells, ie. is angiogenic. TGF- b polypeptide, a homodimer of two 112 chains, is secreted by many different cell types, stimulates wound healing but in vitro is also a growth inhibitor for certain cell types. The TGF family includes many of the bone morphogenetic proteins (BMPs).

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Transforming growth factor — (sometimes referred to as Tumor growth factor, or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGF beta;. The name Transforming Growth Factor is somewhat arbitrary, since the two classes of TGFs are not… …   Wikipedia

  • Transforming Growth Factor — Le TGF ou Transforming growth factor est une cytokine polypeptidique qui est classé en deux groupes : le TGFα, produit par les macrophages, les neurones et les kératinocytes, est un facteur de développement cellulaire et le TGFβ qui agit… …   Wikipédia en Français

  • transforming growth factor — n any of a group of polypeptides that are secreted by a variety of cells (as monocytes, T cells, or blood platelets) and have diverse effects (as inducing angiogenesis, stimulating fibroblast proliferation, or inhibiting T cell proliferation) on… …   Medical dictionary

  • Transforming growth factor — Der Transforming Growth Factor (Abk. TGF, deut. Transformierender Wachstumsfaktor) gehört zu den Zytokinen zählenden Signalmolekülen. Sie sind namensgebend für die TGF Signalwege. TGF spielen eine sehr wichtige Rolle bei der embryonalen… …   Deutsch Wikipedia

  • Transforming Growth Factor — Der Transforming Growth Factor (Abk. TGF, deut. Transformierender Wachstumsfaktor) gehört zu den Zytokinen zählenden Signalmolekülen. Sie sind namensgebend für die TGF Signalwege. TGF spielen eine sehr wichtige Rolle bei der embryonalen… …   Deutsch Wikipedia

  • Transforming growth factor — Le TGF ou transforming growth factor est une cytokine polypeptidique qui est classé en deux groupes : le TGFα, produit par les macrophages, les neurones et les kératinocytes, est un facteur de développement cellulaire et le TGFβ qui agit… …   Wikipédia en Français

  • transforming growth factor — noun : any of a group of polypeptides that are secreted by a variety of cells (as monocytes, T cells, or blood platelets) and have diverse effects (as inducing angiogenesis, stimulating fibroblast proliferation, or inhibiting T cell… …   Useful english dictionary

  • Transforming growth factor, beta 3 — Transforming growth factor, beta 3, also known as TGFB3, is a human gene.cite web | title = Entrez Gene: TGFB3 transforming growth factor, beta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7043|… …   Wikipedia

  • Transforming growth factor beta superfamily — Pfam box Symbol = TGF beta Name = Transforming growth factor beta like domain width = caption = Pfam= PF00019 InterPro= IPR001839 SMART= PROSITE= PDOC00223 SCOP = 1tfg TCDB = OPM family= OPM protein= PDB=PDB3|1ktzA:312 412 PDB3|1tgjA:312 412… …   Wikipedia

  • Growth factor — Dieser Artikel behandelt Wachstumsfaktor als Begriff aus der Biologie. Das Wort wird außerdem verwendet bei der mathematischen Untersuchung von Wachstumsprozessen (siehe Wachstumsfaktor (Mathematik)) Als Wachstumsfaktoren werden Proteine… …   Deutsch Wikipedia

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