Smad proteins


Smad proteins
Intracellular proteins that mediate signalling from receptors for extracellular TGF b -related factors. Smad2 is essential for embryonic mesoderm formation and establishment of anterior-posterior patterning. Smad4 is important in gastrulation. Smads1 and 5 are activated (serine/threonine phosphorylated) by BMP receptors, Smad2 and 3 by activin and TGF b receptors. Smads activated by occupied receptors then form complexes with Smad4/DPC4 and move into the nucleus where they regulate gene expression. Interact with FAST2.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • SMAD — may refer to: * Sowjetische Militäradministration in Deutschland * SMAD (protein) – proteins involved in cell signaling ** R SMAD – receptor regulated SMAD proteins ** I SMAD – inhibitory SMAD proteins * SMAD – a house DJ based in New England …   Wikipedia

  • SMAD (protein) — SMADs are intracellular proteins that transduce extracellular signals from transforming growth factor beta ligands to the nucleus where they activate downstream TGF β gene transcription.[1][2][3][4][5] …   Wikipedia

  • R-SMAD — R Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD9. In response to signals by the TGF β superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an …   Wikipedia

  • Mothers against decapentaplegic homolog 2 — SMAD family member 2 PDB rendering based on 1dev …   Wikipedia

  • Mothers against decapentaplegic homolog 3 — SMAD family member 3 PDB rendering based on 1dev …   Wikipedia

  • Mothers against decapentaplegic homolog 4 — SMAD family member 4 PDB rendering based on 1dd1 …   Wikipedia

  • Mothers against decapentaplegic homolog 6 — SMAD family member 6 Identifiers Symbols SMAD6; HsT17432; MADH6; MADH7 External IDs …   Wikipedia

  • Mothers against decapentaplegic homolog 7 — SMAD family member 7 Solution Structure Of Smurf2 Ww3 Domain Smad7 Py Peptide Complex Identifiers Symbols …   Wikipedia

  • Mothers against decapentaplegic homolog 1 — SMAD family member 1 PDB rendering based on 1khu …   Wikipedia

  • Mothers against decapentaplegic homolog 9 — SMAD family member 9 Identifiers Symbols SMAD9; MADH6; MADH9; SMAD8; SMAD8A; SMAD8B External IDs …   Wikipedia


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