shc
Gene family identified by presence of SH2 domains. Shc also has a tyrosine motif that, when phosphorylated, will bind the SH2 of the adaptor protein grb2 and may link receptor tyrosine kinases with the ras signalling pathway. Overexpression of shc will transform fibroblasts.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

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