- protein kinase C
Family of protein serine/threonine kinases activated by phospholipids that play an important part in intracellular signalling. The classical PKCs ( a, b1, b2, g) are also calcium dependent and can be activated by diacyl glycerol, one of the products of phospholipase C or, non-physiologically, by phorbol esters. A growing set of non-classical calcium independent isoforms are known. The catalytic domain is highly conserved and specific properties are conferred by a variety of regulatory domains including a pseudo-substrate region which is displaced upon activation. The specific physiological substrates for these enzymes are not yet well defined.
Dictionary of molecular biology. 2004.