protease-activated receptor
(= PAR1, 2, 3)
PAR1 is the human thrombin receptor, PAR2 is a possible trypsin receptor and PAR3 is similar to PAR1. All are G-protein-coupled receptors activated by cleavage of part of the extracellular domain at K38/T39: the cleaved fragment then acts as a ligand and stimulates phosphoinositide hydrolysis. Found on platelets and megakaryocytes.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

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