phospholipases
Enzymes that hydrolyze ester bonds in phospholipids. They comprise two types: aliphatic esterases (phospholipase A1, A2 and B) that release fatty acids, and phosphodiesterases (types C and D) that release diacyl glycerol or phosphatidic acid respectively. Type A2 is widely distributed in venoms and digestive secretions. Types A1, A2 and C (the latter specific for phosphatidyl inositol) are present in all mammalian tissues. Type C is also found as a highly toxic secretion product of pathogenic bacteria. Type B attacks monoacyl phospholipids and is poorly characterized. Type D is largely of plant origin. PLA2 Type II (a secreted enzyme, but not the same as the Type I digestive pancreatic enzyme) is probably very important in inflammation because its action can release arachidonic acid, the starting point for eicosanoid synthesis. Phosphatidylinositol bisphosphate-specific phospholipase C is important in generating diacylglycerol and inositol trisphosphate, both second messengers.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Phospholipases — Phospholipase Les phospholipases sont des enzymes qui hydrolysent les phospholipides. On distingue selon le site d’action de l’enzyme : Phospholipase A1 (EC 3.1.1.32) enlève l’acide gras lié à la fonction alcool primaire du glycérol,… …   Wikipédia en Français

  • Phospholipase A2 — Phospholipases A2 (PLA2s) EC number|3.1.1.4 are upstream regulators of many inflammatory processes. This particular phospholipase specifically recognizes the sn 2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing… …   Wikipedia

  • Phospholipase C — Action des différents groupes de phospholipases sur les phospholipides Les phospholipases sont des enzymes hydrolysant les liaisons esters des phospholipides. Il existe quatre liaisons ester dans un phospholipide. On distingue donc plusieurs… …   Wikipédia en Français

  • VENINS — Chez de très nombreux animaux existent des substances toxiques. Certaines d’entre elles sont d’origine végétale. Elles proviennent parfois des plantes dont ces animaux se nourrissent, tels les alcaloïdes que concentrent dans leurs tissus quelques …   Encyclopédie Universelle

  • Snake venom — Contents 1 Chemistry 1.1 Neurotoxins 1.2 Cytotoxins 2 …   Wikipedia

  • PLA2G1B — Phospholipase A2, group IB (pancreas), also known as PLA2G1B, is a human gene.cite web | title = Entrez Gene: PLA2G1B phospholipase A2, group IB (pancreas)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Diffuse axonal injury — Classification and external resources Susceptibility weighted image (SWI) of diffuse axonal injury in trauma at 1.5 teslas (right) eMedicine …   Wikipedia

  • Phosphoinositide phospholipase C — Pfam box Symbol = PI PLC X Name = Phosphatidylinositol specific phospholipase C width = 220px caption =Phospholipase Cδ 1 Pfam= PF00388 InterPro= IPR000909 SMART= PLCXc PROSITE = PDOC50007 SCOP = 1gym TCDB = OPM family= 126 OPM protein= 2plc… …   Wikipedia

  • Phospholipidosis — is a lipid storage disorder in which excess phospholipids accumulate within cells. Drug induced phospholipidosis is an adverse drug reaction that occurs with many cationic amphiphillic drugs. While the mechanism is not truly understood, four… …   Wikipedia

  • Eicosanoid biosynthesis — Eicosanoids are signaling molecules, synthesized by most living creatures. (The IUPAC and the IUBMB use the equivalent term Icosanoid.cite web author=Cyberlipid Center| title=Prostanoids url= http://www.cyberlipid.org/prost1/pros0001.htm#9 |… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”