phosphatidyl inositol
Very important minor phospholipid in eukaryotes, involved in signal transduction processes. Contains myo-inositol linked through the 1-hydroxyl group to phosphatidic acid. The 4-phosphate (PIP) and 4,5 bisphosphate derivatives (PIP2) are formed and broken down in membranes by the action of specific kinases and phosphatases (futile cycles). Signal-sensitive phospholipase C enzymes remove the inositol moiety, in particular from 1,4,5 trisphosphate (PIP2) as inositol 1,4,5-triphosphate (InsP3: IP3). Both the diacyl glycerol and inositol phosphate products act as second messengers.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • glycosyl phosphatidyl inositol — See GPI anchor …   Dictionary of molecular biology

  • Inositol triphosphate — chembox new ImageFile = IP3.png ImageSize = IUPACName = OtherNames = Section1 = Chembox Identifiers Abbreviations = CASNo = 85166 31 0 EINECS = PubChem = 55310 SMILES = InChI = RTECS = MeSHName = ChEBI = KEGG = ATCCode prefix = ATCCode suffix =… …   Wikipedia

  • inositol trisphosphate — (= IP3, InsP3) Inositol 1,4,5 trisphosphate is important as a second messenger. It is released from phosphatidyl inositol bisphosphate by the action of a specific phospholipase C enzyme (PLCg) and binds to and activates a calcium channel in the… …   Dictionary of molecular biology

  • Inositol phosphate — group …   Wikipedia

  • Inositol — myo Inositol[1] …   Wikipedia

  • cyclic inositol phosphates — 1,2 cyclic derivatives of inositol phosphatide that are invariably formed during enzymic hydrolysis of phosphatidyl inositol species. Have been proposed as second messengers in hormone activated pathways …   Dictionary of molecular biology

  • CDP-diacylglycerol-inositol 3-phosphatidyltransferase — In enzymology, a CDP diacylglycerol inositol 3 phosphatidyltransferase (EC number|2.7.8.11) is an enzyme that catalyzes the chemical reaction:CDP diacylglycerol + myo inositol ightleftharpoons CMP + phosphatidyl 1D myo inositolThus, the two… …   Wikipedia

  • PI-3-kinases — (= phosphatidyl inositol 3 kinases; PI kinases) Lipid kinases that phosphorylate phosphatidylinositol phosphate on the 3 position.Now recognised to be key enzymes acting downstream of many receptors, particularly receptor tyrosine kinases such as …   Dictionary of molecular biology

  • PIP2 — (= phosphatidyl inositol 4,5,bisphosphate) …   Dictionary of molecular biology

  • Phosphoinositide 5-phosphatase — In enzymology, a phosphoinositide 5 phosphatase (EC number|3.1.3.36) is an enzyme that catalyzes the chemical reaction:1 phosphatidyl 1D myo inositol 4,5 bisphosphate + H2O ightleftharpoons 1 phosphatidyl 1D myo inositol 4 phosphate +… …   Wikipedia

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