phorbol esters
Polycyclic compounds isolated from croton oil in which two hydroxyl groups on neighbouring carbon atoms are esterified to fatty acids. The commonest of these derivatives is phorbol myristoyl acetate (PMA). Potent co-carcinogens or tumour promotors, they are diacyl glycerol analogues and activate protein kinase C irreversibly.

Dictionary of molecular biology. 2004.

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  • phorbol — The parent alcohol of the cocarcinogens, which are 12,13(9,9a) diesters of p. found in croton oil; the hydrocarbon skeleton is a cyclopropabenzazulene; p. esters mimic 1,2 diacylglycerol as activators of protein kinase C. * * * phor·bol fȯr… …   Medical dictionary

  • Phorbol — Chembox new Name = Phorbol ImageFile = Phorbol.png ImageName = Phorbol IUPACName = 1,1a,1b,4,4a,7a,7b,8,9,9a decahydro 4a,7b,9,9a tetrahydroxy 3 (hydroxymethyl) 1,1,6,8 tetramethyl 5H cyclopropa [3,4] benz [1,2 e] azulen 5 one Section1 = Chembox… …   Wikipedia

  • phorbol ester — any of several esters of phorbol that are potent cocarcinogens; they are structurally similar to diacylglycerol and can activate protein kinase C. They are used frequently in research to enhance the induction of mutagenesis or tumors by… …   Medical dictionary

  • phorbol — ˈfȯrˌbȯl, ˌbōl noun ( s) Etymology: International Scientific Vocabulary phorb (from Greek phorbē pasture, fodder) + ol (I); originally formed in German more at pheophorbide : an alcohol C20H28O …   Useful english dictionary

  • C1 domain — Pfam box Symbol = C1 1 Name = Phorbol esters/diacylglycerol binding domain (C1 domain) width =200 caption = C1 domain of PKC delta (1ptr) Middle plane of the lipid bilayer black dots. Boundary of the hydrocarbon core region blue dots (cytoplasmic …   Wikipedia

  • RASGRP3 — RAS guanyl releasing protein 3 (calcium and DAG regulated), also known as RASGRP3, is a human gene.cite web | title = Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG regulated)| url =… …   Wikipedia

  • Chimerin 2 — Chimerin (chimaerin) 2 PDB rendering based on 1xa6 …   Wikipedia

  • Croton tiglium — Purging Croton Croton tiglium Scientific classification Kingdom: Plantae …   Wikipedia

  • PKC alpha — Protein kinase C, alpha, also known as PRKCA, is a human gene. PBB Summary section title = summary text = Protein kinase C (PKC) is a family of serine and threonine specific protein kinases that can be activated by calcium and the second… …   Wikipedia

  • PRKCD — Protein kinase C, delta, also known as PRKCD, is a human gene. PBB Summary section title = summary text = Protein kinase C (PKC) is a family of serine and threonine specific protein kinases that can be activated by calcium and the second… …   Wikipedia

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