- pertussis toxin
Protein complex (ca 117 kD). An AB toxin, the active subunit is a single polypeptide (28 kD), the binding subunit a pentamer (two heterodimers, 23 + 11.7 kD, 11.7 + 22 kD, and a monomer (9.3 kD) that binds the heterodimers). The active subunit ADP-ribosylates the a subunit of the inhibitory GTP-binding protein (Gi). Crucial to the pathogenicity of Bordetella pertussis, the causative agent of whooping cough.
Dictionary of molecular biology. 2004.