(= apoptosis protease activating factor 1)
Protein that binds to cytochrome c that has been released from mitochondria and links with caspase-9 which then activates caspase-3, initiating a cascade of events that end in apoptotic death of the cell.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

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  • Apaf-1 — (apoptotic protease activating factor 1) is a cytosolic protein involved in cell death or apoptosis. When Cytochrome c is released from the mitochondria, it interacts with Apaf 1 and dATP to form the apoptosome, a large oligomeric protein complex …   Wikipedia

  • Apaf-1 — apoptotic protease activating factor 1 * * * apoptotic protease activating factor 1 …   Medical dictionary

  • Apaf-1 — • apoptotic protease activating factor 1 …   Dictionary of medical acronyms & abbreviations

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  • apoptotic protease activating factor 1 — (Apaf 1) a cytoplasmic protein that is activated by cytochrome c (released from mitochondria) and deoxyadenosine triphosphate (dATP); it in turn binds to and activates caspase 9, initiating the apoptotic cascade …   Medical dictionary

  • APAF1 — APAF 1 (Apoptotic peptidase activating factor 1) est une protéine qui rentre dans la composition de l apoptosome qui joue un rôle dans la voie intrinsèque de l apoptose. Elle se lie au cytochrome C provenant de l espace intermembranaire de de la… …   Wikipédia en Français

  • Caspase-9 — Caspase 9, apoptosis related cysteine peptidase PDB rendering based on 1jxq …   Wikipedia

  • APAF1 — Apoptotic peptidase activating factor 1, also known as APAF1, is a human gene. PBB Summary section title = summary text = This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD 40 domain,… …   Wikipedia

  • Апоптоз — …   Википедия

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