antibody dependent cell-mediated cytotoxicity
(= ADCC)
Killing of target cells by lymphocytes or other leucocytes that carry antibody specific for the target cell, attached to their Fc receptors. The cell involved in the killing may be a passive carrier of the antibody.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Antibody-dependent cell-mediated cytotoxicity — (ADCC) is a mechanism of cell mediated immunity whereby an effector cell of the immune system actively lyses a target cell that has been bound by specific antibodies. It is one of the mechanisms through which antibodies, as part of the humoral… …   Wikipedia

  • Antibody-dependent cell-mediated cytotoxicity — An immune response in which antibody, by coating target cells, makes them vulnerable to attack by immune cells. Antibody dependent cell mediated cytotoxicity is commonly (and blissfully) abbreviated ADCC. * * * (ADCC), antibody dependent cellular …   Medical dictionary

  • antibody-dependent cell-mediated cytotoxicity — (ADCC) The killing of antibody coated target cells by cells with Fc receptors that recognize the Fc region of the bound antibody. Most ADCC is mediated by NK cells that have the Fc receptor or CD16 on their surface …   Dictionary of microbiology

  • cell-mediated cytotoxicity — cytolysis of a target cell by effector lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody dependent (see antibody dependent cell mediated c.) or independent, as in certain type IV hypersensitivity reactions (q.v.) …   Medical dictionary

  • Cytotoxicity — is the quality of being toxic to cells. Examples of toxic agents are a chemical substance, an immune cell or some types of venom (e.g. from the puff adder or brown recluse spider). Contents 1 Cell physiology 2 Measuring cytotoxicity …   Wikipedia

  • Cell — The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane. Each cell in the human body there are 100 trillion cells in each of us contains the entire… …   Medical dictionary

  • cytotoxicity — The quality or state of being cytotoxic. antibody dependent cell mediated c. (ADCC) a form of cell mediated c. that functions by binding of the FC region of IgG antibodies to Fc receptors on leukocytes. The FAB region of the antibody binds to the …   Medical dictionary

  • Monoclonal antibody therapy — Each antibody binds only one specific antigen. Monoclonal antibody therapy is the use of monoclonal antibodies (or mAb) to specifically bind to target cells or proteins. This may then stimulate the patient s immune system to attack those cells.… …   Wikipedia

  • Natural killer cell — Latin lymphocytus K Code TH H2.00.04.1.02006 Natural killer cells (or NK cells) are a type of cytotoxic lymphocyte that constitute a major component of the innate immune system. NK cells play a major role in the rejection of …   Wikipedia

  • ADCC — Antibody dependent cell mediated cytotoxicity, an immune response in which antibody, by coating target cells, makes them vulnerable to attack by immune cells. Antibody dependent cell mediated cytotoxicity is commonly (and blissfully) abbreviated… …   Medical dictionary

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