nitroblue tetrazolium reduction
Nitroblue tetrazolium, a yellow dye, is taken up by phagocytosing neutrophils and reduced to insoluble formazan, which is deep-blue, if the metabolic burst is normal. Reduction does not take place in chronic granulomatous disease.

Dictionary of molecular biology. 2004.

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  • nitroblue tetrazolium test — (for neutrophil microbicidal function) neutrophils are incubated with latex particles and nitroblue tetrazolium (NBT). Normally phagocytosis of the particles is accompanied by reduction of NBT to a blue formazan pigment; absence of NBT reduction… …   Medical dictionary

  • nitroblue tetrazolium — ni·tro·blue tet·ra·zo·li·um (niґtro bloo tet″rə zoґle əm) a yellow water soluble dye that on reduction is converted to a dark blue water insoluble formazan; see also under test …   Medical dictionary

  • Cloruro de nitroblue tetrazolium — Nombre (IUPAC) …   Wikipedia Español

  • tetrazolium — Any of a group of organic salts having the general structure that on reduction (cleaving the 2,3 bond) yields a colored insoluble formazan; used as a reagent in oxidative enzyme histochemistry. nitroblue t. ( …   Medical dictionary

  • NBT — (= nitroblue tetrazolium) See nitroblue tetrazolium reduction …   Dictionary of molecular biology

  • Gundu Hirisave Rama Rao — was born in Tumkur (Karnataka), India, on 23 August 1937. He is a scientist, entrepreneur and a tenured professor at the Academic Health Center, University of Minnesota. He and Professor John Eaton visited India in 1981 under a National Science… …   Wikipedia

  • formazan — A water insoluble colored compound of the general structure, RNH N=CR′ N=NR″, formed by reduction of a tetrazolium salt in the histochemical demonstration of oxidative enzymes; the R s are usually phenyl groups; examples include neotetrazolium,… …   Medical dictionary

  • test — 1. To prove; to try a substance; to determine the chemical nature of a substance by means of reagents. 2. A method of examination, as to determine the presence or absence of a definite disease or of some substance in any of the fluids, tissues,… …   Medical dictionary

  • Chronic granulomatous disease — Classification and external resources Superoxide ICD 10 D …   Wikipedia

  • fructosamine test — determination of the serum fructosamine level by measurement of the reduction of nitroblue tetrazolium to purple under alkaline conditions; it is used as an index of the average glycemic state over the preceding two to three weeks and is used to… …   Medical dictionary

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