myosin light chains
Small subunit proteins (17-22 kD) of myosin II, all with sequence homology to calmodulin, but not all with calcium-binding activity: two pairs of different light chains are found per myosin. Several types are known: regulatory light-chains (LC-2, DNTB-light-chains) probably regulate the ATPase activity of the heavy chain directly (through the binding of calcium) or indirectly (activating when they themselves are phosphorylated by myosin light chain kinase), and essential light chains (LC-1, LC-3; alkali light-chains), which have a more subtle and apparently non-essential role. In molluscan muscle the EDTA-light chains (similar to LC-2 from vertebrate muscle) confer calcium-sensitivity on the myosin itself.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Myosin light chain — Part of the myosin II structure. Atoms in the heavy chain are colored red on the left hand side, and atoms in the light chains are colored orange and yellow. Myosin light chain is a subunit of myosin [1] Myosin light chains are distinct and have… …   Wikipedia

  • myosin light chain kinase — (= MLCK) Calmodulin regulated kinase of myosin II light chains: molecular weight varies according to source, 130 kD in non muscle mammalian cells. May regulate activity of myosin in some cells …   Dictionary of molecular biology

  • Myosin — Part of the myosin II structure. Atoms in the heavy chain are colored red on the left hand side, and atoms in the light chains are colored orange and yellow. Myosins comprise a family of ATP dependent motor proteins and are best known for their… …   Wikipedia

  • myosin — A family of motor ATPases that interact with F actin filaments. An increasing number of different myosins are being described. Classical striated muscle myosin is myosin II. (See also myosin light chains, meromyosin.) Myosin I is a low molecular… …   Dictionary of molecular biology

  • Myosin head — scallop myosin in the near rigor conformation Identifiers Symbol Myosin head Pfam …   Wikipedia

  • myosin — A globulin present in muscle that has an ATPase activity; in combination with actin, it forms actomyosin; m. forms the thick filaments in muscle. m. light chain kinase a calcium/ …   Medical dictionary

  • EDTA-light chain — Myosin light chains (18 kD) from scallop muscle (two per pair of heavy chains), easily extracted by calcium chelation. Although the EDTA light chains do not bind calcium they confer calcium sensitivity on the myosin heavy chains …   Dictionary of molecular biology

  • MYL4 — Myosin, light chain 4, alkali; atrial, embryonic, also known as MYL4, is a human gene.cite web | title = Entrez Gene: MYL4 myosin, light chain 4, alkali; atrial, embryonic| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView …   Wikipedia

  • MYL1 — Myosin, light chain 1, alkali; skeletal, fast, also known as MYL1, is a human gene.cite web | title = Entrez Gene: MYL1 myosin, light chain 1, alkali; skeletal, fast| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • MYL6 — Myosin, light chain 6, alkali, smooth muscle and non muscle, also known as MYL6, is a human gene.cite web | title = Entrez Gene: MYL6 myosin, light chain 6, alkali, smooth muscle and non muscle| url =… …   Wikipedia

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