metabolic burst


metabolic burst
(= respiratory burst)
Response of phagocytes to particles (particularly if opsonized), and to agonists such as formyl peptides and phorbol esters; an enhanced uptake of oxygen leads to the production, by an NADH-dependent system, of hydrogen peroxide, superoxide anions, and hydroxyl radicals, all of which play a part in bactericidal activity. Defects in the metabolic burst, as in chronic granulomatous disease, predispose to infection particularly with catalase-positive bacteria, and are usually fatal in childhood.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • metabolic burst — respiratory b …   Medical dictionary

  • burst — A sudden increase in activity. respiratory b. the marked increase in metabolic activity that occurs in phagocytes and certain other cells following binding of particles resulting in an increase in oxygen consumption, formation of su …   Medical dictionary

  • respiratory burst — See metabolic burst …   Dictionary of molecular biology

  • respiratory burst — The respiratory burst occurs when an activated phagocytic cell increases its oxygen consumption to support the increased metabolic activity of phagocytosis. The burst generates highly toxic oxygen products such as singlet oxygen, superoxide… …   Dictionary of microbiology

  • respiratory burst — a sequence of four metabolic events that occur during oxidative killing of ingested microorganisms by granulocytes and mononuclear phagocytes, consisting of (1) an increase in oxygen consumption, (2) formation of superoxide anion, (3) formation… …   Medical dictionary

  • antioxidant — Any substance that inhibits oxidation usually because it is preferentially oxidised itself. Common examples are vitamin E ( a tocopherol) and vitamin C. Important for trapping free radicals generated during the metabolic burst and possibly for… …   Dictionary of molecular biology

  • lucigenin — Compound used as a bystander substrate in assaying the metabolic burst of leucocytes by chemiluminescence. When oxidized by superoxide it emits light …   Dictionary of molecular biology

  • luminol — Compound used as a bystander substrate in assaying the metabolic burst of leucocytes by chemiluminescence. When oxidized by the myeloperoxidase/hydrogen peroxide system, it emits light …   Dictionary of molecular biology

  • myeloperoxidase — A metallo enzyme containing iron, found in the lysosomal granules of myeloid cells, particularly macrophages and neutrophils; responsible for generating potent bacteriocidal activity by the hydrolysis of hydrogen peroxide (produced in the… …   Dictionary of molecular biology

  • nitroblue tetrazolium reduction — Nitroblue tetrazolium, a yellow dye, is taken up by phagocytosing neutrophils and reduced to insoluble formazan, which is deep blue, if the metabolic burst is normal. Reduction does not take place in chronic granulomatous disease …   Dictionary of molecular biology


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.