ligand-gated ion channel


ligand-gated ion channel
A transmembrane ion channel whose permeability is increased by the binding of a specific ligand, typically a neurotransmitter at a chemical synapse. The permeability change is often drastic; such channels let through effectively no ions when shut, but allow passage at up to 107 ions s-1 when a ligand is bound. Recently, the receptors for both acetylcholine and GABA have been found to share considerable sequence homology, implying that there may be a family of structurally related ligand-gated ion channels.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Ligand-gated ion channel — Neurotransmitter gated ion channel transmembrane region Ligand gated ion channel Identifiers Symbol Neur chan memb Pfam …   Wikipedia

  • gated ion channel — Transmembrane proteins of excitable cells, that allow a flux of ions to pass only under defined circumstances. Channels may be either voltage gated, such as the sodium channel of neurons, or ligand gated such as the acetylcholine receptor of… …   Dictionary of molecular biology

  • Light-gated ion channel — Light gated ion channels are a group of transmembrane proteins that form ion channels; pores which open or close in response to light. Most light gated ion channels have been synthesized in the laboratory for study, though one naturally occurring …   Wikipedia

  • Cyclic nucleotide-gated ion channel — Cyclic nucleotide gated (CNG) ion channels are ion channels that function in response to the binding of cyclic nucleotides. CNG channels are nonselective cation channels that are found in the membranes of various types of cells. Signal… …   Wikipedia

  • ligand-gated — adj permitting or blocking passage through a cell membrane in response to a chemical stimulus <a ligand gated ion channel triggered by ATP (J. M. Besson)> …   Medical dictionary

  • Ion channel — Not to be confused with: Ion Television or Ion implantation. Schematic diagram of an ion channel. 1 channel domains (typically four per channel), 2 outer vestibule, 3 selectivity filter, 4 diameter of selectivity filter, 5 phosphorylation site, 6 …   Wikipedia

  • ligand-gated — ˈ ̷ ̷  ̷ ̷ ˈ ̷ ̷  ̷ ̷ adjective : permitting or blocking passage through a cell membrane in response to a chemical stimulus a ligand gated ion channel triggered by ATP J.M.Besson …   Useful english dictionary

  • Ion channel linked receptors — are cell membrane bound receptors. They act through synaptic signaling on electrically excitable cells. The ion channels opening and closing is controlled by neurotransmitters.Ion channel linked receptors are also called ligand gated channels .… …   Wikipedia

  • ligand-gated channel — an ion channel that opens in response to the binding of a molecule (the ligand) to the channel protein, which causes a conformational change in the protein molecule. Cf. voltage gated c …   Medical dictionary

  • ion channel — A transmembrane pore that presents a hydrophilic channel for ions to cross a lipid bilayer down their electrochemical gradients. Some degree of ion specificity is usually observed, and typically a million ions per second may flow. Channels may be …   Dictionary of molecular biology


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.