amyloid precursor protein
Individuals with Alzheimer\'s disease are characterized by extensive accumulation of amyloid in the brain, referred to as senile plaques. These consist of a core of amyloid fibrils surrounded by dystrophic neurites. The principal component of the amyloid fibrils is B/A4, a peptide derived from the larger APP. The specific role of amyloid protein is unclear but it is thought that amyloid deposits may cause neurons to degenerate. Amyloid deposits also occur in brains of older Down\'s Syndromepatients.

Dictionary of molecular biology. 2004.

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  • Amyloid precursor protein — (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formationPriller C, Bauer T, Mitteregger G,… …   Wikipedia

  • Amyloid-Precursor-Protein — Masse/Länge Primärstruktur 753 Aminosäuren …   Deutsch Wikipedia

  • amyloid precursor protein — n a transmembrane protein from which beta amyloid is derived by proteolytic cleavage by secretases abbr. APP * * * (APP) a large transmembrane glycoprotein expressed on the cell surface, of uncertain function; it may be cleaved on the cell… …   Medical dictionary

  • Amyloid Precursor Protein — Protéine précurtrice de l amyloïde Pour les articles homonymes, voir APP. Structure PDB de la protéine précurseur de l amyloïde …   Wikipédia en Français

  • serum amyloid A protein — a high molecular weight protein synthesized in the liver; it is an acute phase protein and circulates in association with a subclass of HDL lipoproteins. It is the precursor to AA amyloid and accumulates in inflammation. Called also SAA p …   Medical dictionary

  • Amyloid-beta — Beta Amyloid Stäbchen /Bändermodell von Aβ42; nach PDB  …   Deutsch Wikipedia

  • Amyloid — Amyloids are insoluble fibrous protein aggregates sharing specific structural traits. Abnormal accumulation of amyloid in organs may lead to amyloidosis, and may play a role in various other neurodegenerative diseases. Definition controversyThe… …   Wikipedia

  • amyloid — Glycoprotein deposited extracellularly in tissues in amyloidosis. The glycoprotein may either derive from light chain of immunoglobulin (AIO (amyloid of immune origin): 5 18 kD glycoprotein; product of a single clone of plasma cells, the N… …   Dictionary of molecular biology

  • Protein C — Not to be confused with C peptide, C reactive protein, or protein kinase C. Protein C (inactivator of coagulation factors Va and VIIIa) Tertiary structure of human activated protein C (minus the Gla domain …   Wikipedia

  • Beta amyloid — protein Name = amyloid beta (A4) precursor protein (peptidase nexin II, Alzheimer disease) caption = Processing of the amyloid precursor protein width = 300 HGNCid = 620 Symbol = APP AltSymbols = AD1 EntrezGene = 351 OMIM = 104760 RefSeq = NM… …   Wikipedia

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