LECAM


LECAM
(= CD62L; LAM-1; L-selectin; MEL-14 antigen; leu-8)
Leucocyte-endothelial cell adhesion molecule (37 kD polypeptide), a selectin, expressed on most haematopoietic cells and on mature monocytes, eosinophils and neutrophils. Important for initial adhesion step (margination) and is then rapidly lost from cell surface through activity of a membrane associated sheddase, a metalloproteinase. Important function is in lymphocyte homing to high endothelial venule in peripheral lymph nodes, Peyer&’s patches and areas of inflammation. Has N-terminal C-type lectin domain and binds particularly to carbohydrates on CD34, CD162, GlyCam and MAdCAM.

Dictionary of molecular biology. 2004.

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