(= IL-17)Pro-inflammatory T-cell product (17 kD) that acts on receptors on a range of cells to activate NF k B. Induces expression of IL-6, IL-8 and ICAM-1 in fibroblasts and enhances T-cell proliferation stimulated by sub-optimal levels of PHA. Receptor is a Type I transmembrane protein, though a soluble form is also found, and has no homology with other known sequences.
Dictionary of molecular biology. 2004.
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