immunosuppression


immunosuppression
This occurs when T- and/or B-clones of lymphocytes are depleted in size or suppressed in their reactivity, expansion or differentiation. It may arise from activation of specific or nonspecific T-suppressor lymphocytes of either T- or B-clones, or by drugs that have generalized effects on most or all T- or B-lymphocytes. Cyclosporin A and FK506 act on T-cells, as does antilymphocyte serum; alkylating agents such as cyclophosphamide are less specific in their action and damage DNA replication, while base analogues interfering with guanine metabolism act in a similar way. See immunophilin.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Immunosuppression — involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to …   Wikipedia

  • Immunosuppression — vgl. Immunsuppression …   Das Wörterbuch medizinischer Fachausdrücke

  • immunosuppression — [im΄yə nōsə presh′ən, ī myo͞o′nōsə presh′ən] n. the inactivation of a specific antibody by various agents, thus permitting the acceptance of a foreign substance, as a transplant, by an organism immunosuppressant adj. immunosuppressive …   English World dictionary

  • immunosuppression — ● immunodépression ou immunosuppression nom féminin Diminution, voire suppression, des réactions immunitaires. immunosuppression [i(m)mynosypʀesjɔ̃] n. f. ÉTYM. Mil. XXe (1965 en angl.); de immuno , et suppression. ❖ ♦ Biol., méd. Processus par… …   Encyclopédie Universelle

  • Immunosuppression — L immunosuppression ou immuno inhibition est la suppression médicale du système immunitaire. Elle est généralement réalisée pour empêcher le corps de rejeter une greffe d organe. Quand un organe est greffé, le système immunitaire du receveur va… …   Wikipédia en Français

  • immunosuppression — immunosuppressed, adj. /im yeuh noh seuh presh euhn, i myooh /, n. Pathol. the inhibition of the normal immune response because of disease, the administration of drugs, or surgery. [1960 65; IMMUNO + SUPPRESSION] * * * Suppression of immunity… …   Universalium

  • immunosuppression — Suppression of the body s immune system and its ability to fight infections or disease. Immunosuppression may be deliberately induced with drugs, as in preparation for bone marrow or other organ transplantation to prevent rejection of the donor… …   English dictionary of cancer terms

  • immunosuppression — noun Date: 1963 suppression (as by drugs) of natural immune responses • immunosuppress transitive verb • immunosuppressant noun or adjective • immunosuppressive adjective …   New Collegiate Dictionary

  • immunosuppression — noun The active medical suppression of the immune response. See Also: immunosuppressant, immunosuppressive, immunosuppressor …   Wiktionary

  • immunosuppression — Prevention or interference with the development of immunologic response; may reflect natural immunologic unresponsiveness (tolerance), may be artificially induced by chemical, biological, or physical agents, or may be caused by disease. * * *… …   Medical dictionary


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