homologous recombination


homologous recombination
Genetic recombination involving exchange of homologous loci. Important technique in the generation of null alleles (knockouts) in transgenic mice.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Homologous recombination — Figure 1. During meiosis, homologous recombination can produce new combinations of genes as shown here between similar but not identical copies of human chromosome 1. Homologous recombination is a type of genetic recombination in which nucleotide …   Wikipedia

  • homologous recombination — noun The exchange of DNA between regions of homologous chromosomes that occurs during meiosis …   Wiktionary

  • homologous recombination — The exchange of DNA fragments between the two non sister chromatids of the same chromosome in the course of meiosis …   Glossary of Biotechnology

  • Non allelic homologous recombination — (NAHR) is a form of homologous recombination that occurs between two lengths of DNA that have high sequence homology, but are not alleles.[1][2] It usually occurs between sequences of DNA that have been previously duplicated through evolution,… …   Wikipedia

  • homologous — (1) Derived from the tissues or DNA of a member of the same species. cf heterologous, autologous, homologous recombination. (2) Of genes, similar in sequence, cf. analogous …   Dictionary of molecular biology

  • Recombination — The trading of fragments of genetic material between chromosomes before the egg and sperm cells are created. Key features of recombination include the point to point association of paired chromosomes (synapsis) followed by the visible exchange of …   Medical dictionary

  • recombination — The creation, by a process of intermolecular exchange, of chromosomes combining genetic information from different sources, typically two genomes of a given species. Site specific, homologous, transpositional and non homologous (illegitimate)… …   Dictionary of molecular biology

  • recombination nodule — Protein containing assemblies of about 90nm diameter placed at intervals in the synaptonemal complexes that develop between homologous chromosomes at the zygotene stage of meiosis. Some nodules may be associated with the site of recombination …   Dictionary of molecular biology

  • recombination — The production of a DNA molecule with segments derived from more than one parent DNA molecule. In eukaryotes, this is achieved by the reciprocal exchange of DNA between non sister chromatids within an homologous pair of chromosomes during… …   Glossary of Biotechnology

  • Non-homologous end joining — (NHEJ) is a pathway that repairs double strand breaks in DNA. NHEJ is referred to as non homologous because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.