HMG-CoA reductase
(EC 1.1.1.34) Integral membrane protein (97 kD) of ER and peroxisomes that catalyses reaction between hydroxy-methyl-glutaryl-CoA and two molecules of NADPH to produce mevalonate, a key starting material for the synthesis of cholesterol and other sterols. Because the enzyme is rate-limiting in synthesis it has made a good target for cholesterol-lowering drugs.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • HMG-CoA reductase — protein Name = 3 hydroxy 3 methylglutaryl Coenzyme A reductase caption = HMG CoA reductase width = 200 HGNCid = 5006 Symbol = HMGCR AltSymbols = EntrezGene = 3156 OMIM = 142910 RefSeq = NM 000859 UniProt = P04035 PDB = ECnumber = 1.1.1.88… …   Wikipedia

  • HMG-CoA réductase — Cholestérol Cholestérol Structure du cholestérol Général Nom IUPAC 10,13 diméthyl 17 (6 méthylheptan 2 yl) 2,3,4,7,8,9,11,12,14,15 …   Wikipédia en Français

  • HMG-CoA reductase — noun a liver enzyme that is responsible for producing cholesterol • Syn: ↑5 hydroxy 3 methylglutaryl coenzyme A reductase • Hypernyms: ↑reductase …   Useful english dictionary

  • HMG CoA reductase — hydroxymethylglutaryl coenzyme A reductase: the key rate limiting enzyme that is involved in the production of cholesterol in the liver. Inhibition of its action is the mechanism by which the statin group of lipid lowering agents work …   The new mediacal dictionary

  • HMG-CoA reductase inhibitor — Hydroxymethylglutaryl coenzyme A reductase inhibitor. A substance that blocks an enzyme needed by the body to make cholesterol and lowers the amount of cholesterol in the blood. HMG CoA reductase inhibitor drugs are called statins. Also called… …   English dictionary of cancer terms

  • HMG-CoA reductase inhibitors — a group of drugs that competitively inhibit the enzyme hydroxymethylglutaryl CoA reductase, which catalyzes the rate limiting step in cholesterol biosynthesis; used to lower plasma lipoprotein levels in treatment of hyperlipoproteinemia. Called… …   Medical dictionary

  • Inhibiteur de la HMG-CoA réductase — Statine Les statines (ou inhibiteurs de la HMG CoA réductase) forment une classe d hypolipidémiants, utilisés comme médicaments pour baisser la cholestérolémie de personnes qui risquent une maladie cardiovasculaire à cause de leur… …   Wikipédia en Français

  • HMG-CoA — Chembox new ImageFile=HMG coenzyme A.svg ImageSize=300px IUPACName=(9R,21S) 1 [(2R,3S,4R,5R) 5 (6 amino 9H purin 9 yl) 4 hydroxy 3 (phosphonooxy)tetrahydrofuran 2 yl] 3,5,9,21 tetrahydroxy 8,8,21 trimethyl 10,14,19 trioxo 2,4,6 trioxa 18 thia… …   Wikipedia

  • HMG-CoA-Reduktase — Stäbchenmodell des Dimers mit Kalotten: Coenzym A (blau), β Hydroxy β methyl glutarylsäure (rot) und NADP (gr …   Deutsch Wikipedia

  • Inhibiteur de l'HMG co-réductase — Statine Les statines (ou inhibiteurs de la HMG CoA réductase) forment une classe d hypolipidémiants, utilisés comme médicaments pour baisser la cholestérolémie de personnes qui risquent une maladie cardiovasculaire à cause de leur… …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”