hepatocyte growth factor


hepatocyte growth factor
Polypeptide mitogen originally shown to cause cell division in hepatocytes. In the liver, the main sources of HGF are non-parenchymal cells. It is now clear that HGF is a mitogen for a number of cell types and it is found in many cells outside the liver, including platelets. HGF is synthesized as a single chain precursor that is proteolytically cleaved to give a heavy chain (70 kD) and a light chain (30 kD) linked by a single disulphide bond. It contains multiple copies of the kringle domain. However, both the single chain precursor and the two-chain forms of HGF are biologically active and HGF is generally isolated as a mixture of the two forms. HGF also alters cell motility and is now known to be identical to scatter factor.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Hepatocyte growth factor — Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on… …   Wikipedia

  • hepatocyte growth factor — (HGF) a potent mitogen and inducer of hepatocyte proliferation, produced by nonparenchymal cells in the liver and by mesenchymal cells in many other organs. Called also scatter f …   Medical dictionary

  • Growth factor — The term growth factor refers to a naturally occurring protein capable of stimulating cellular growth, [DorlandsDict|three/000038554|growth factor] proliferation and cellular differentiation. Growth factors are important for regulating a variety… …   Wikipedia

  • Growth factor — Dieser Artikel behandelt Wachstumsfaktor als Begriff aus der Biologie. Das Wort wird außerdem verwendet bei der mathematischen Untersuchung von Wachstumsprozessen (siehe Wachstumsfaktor (Mathematik)) Als Wachstumsfaktoren werden Proteine… …   Deutsch Wikipedia

  • Hepatocyte nuclear factor 4 alpha — Hepatocyte nuclear factor 4, alpha PDB rendering based on 1m7w …   Wikipedia

  • Transforming growth factor — Der Transforming Growth Factor (Abk. TGF, deut. Transformierender Wachstumsfaktor) gehört zu den Zytokinen zählenden Signalmolekülen. Sie sind namensgebend für die TGF Signalwege. TGF spielen eine sehr wichtige Rolle bei der embryonalen… …   Deutsch Wikipedia

  • Transforming Growth Factor — Der Transforming Growth Factor (Abk. TGF, deut. Transformierender Wachstumsfaktor) gehört zu den Zytokinen zählenden Signalmolekülen. Sie sind namensgebend für die TGF Signalwege. TGF spielen eine sehr wichtige Rolle bei der embryonalen… …   Deutsch Wikipedia

  • Nerve growth factor — (beta polypeptide) Rendering of NGF from PDB 1SG1 …   Wikipedia

  • Epidermal growth factor receptor — This article is about a cell surface receptor. For estimated measure of kidney function (eGFR), see Glomerular filtration rate. Epidermal growth factor receptor …   Wikipedia

  • Low-affinity nerve growth factor receptor — P75 redirects here. For the New Testament manuscript, see Papyrus 75. For Pentium processor at 75 MHz, see Intel P5 (microarchitecture). Nerve growth factor receptor PDB rendering based on 1sg1 …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.