A motif associated with transcription factors, allowing them to bind to and recognize specific DNA sequences. Two amphipathic alpha-helices are separated by a short sequence with a beta pleated sheet. One helix lies across the major groove of the DNA, while the recognition helix enters the major groove and interacts with specific bases. An example in Drosophila is the homeotic gene fushi tarazu, that binds to the sequence TCAATTAAATGA. Not the same as helix-loop-helix.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • helix-turn-helix — helix turn helix. См. спираль петля спираль. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Helix-turn-helix — In proteins, the helix turn helix (HTH) is a major structural motif capable of binding DNA. It is composed of two α helices joined by a short strand of amino acids and is found in many proteins that regulate gene expression. It should not to be… …   Wikipedia

  • Helix-Turn-Helix-Motiv — Das Repressorprotein des Lamda Bakteriophagen bindet mittels eines Helix Turn Helix Motivs (in der Visualisierung grün) an DNA (In der Visualisierung blau und rot), nach PDB 1LMB. Das Helix Turn Helix Motiv (HTH) ist ein Sekundärstruk …   Deutsch Wikipedia

  • Helix-turn-helix-Transkriptionsfaktoren — Das Helix Turn Helix Motiv (HTH) ist ein Sekundärstrukturelement in Proteinen. Es ist Bestandteil von DNA bindenden Proteinen mit sequenzspezifischer DNA Bindedomäne und setzt sich aus zwei α Helices zusammen, die durch einen kurzen β Faltblatt… …   Deutsch Wikipedia

  • Winged helix turn helix — The winged helix turn helix (wHTH) (SCOP|46785) is a DNA binding domain which binds to specific DNA sequences. It is formed by a 3 helical bundle and a 3 or 4 strand beta sheet (wing). Topology of helices and strands in the wHTH families may vary …   Wikipedia

  • helix-loop-helix — A motif associated with transcription factors, allowing them to recognize and bind to specific DNA sequences. Two alpha helices are separated by a loop. Examples: myoblast MyoD 1, c myc, Drosophila genes daughterless, hairy, twist, scute, achaete …   Dictionary of molecular biology

  • Helix-loop-helix-Transkriptionsfaktoren — sind ein Strukturmotiv DNA bindender Proteine, das aus einer kurzen α Helix besteht, die durch eine flexible Schleife (engl. loop) mit einer zweiten längeren Helix verknüpft ist. Dieses HLH Motiv unterscheidet sich vom Helix Turn Helix Motiv.… …   Deutsch Wikipedia

  • Helix — This article is about the shape. For other uses, see Helix (disambiguation). The helix (cos t, sin t, t) from t = 0 to 4π with arrowheads showing direction of increasing t …   Wikipedia

  • helix — 1. [NA] The margin of the auricle; a folded rim of cartilage forming the upper part of the anterior, the superior, and the greater part of the posterior edges of the auricle. 2. A line in the shape of a coil (or a spring, or the threads on a bo …   Medical dictionary

  • Helix-coil transition model — Helix coil transition models are formalized techniques in statistical mechanics developed to describe conformations of linear polymers in solution. The models are usually but not exclusively applied to polypeptides as a measure of the relative… …   Wikipedia

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