Disorders due to abnormalities in the haemoglobin molecule, the best known being sickle-cell anaemia in which there is a single amino acid substitution (valine for glutamate) in position 6 of the b chain. In other cases one of the globin chains is synthesized at a slower rate, despite being normal in structure. See also thalassemia.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

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