GTPase-activating protein
Originally purified as a 125 kD protein from bovine brain (1044 amino acids) ; stimulates the GTPase activity of ras-p21 and thereby switches it to the inactive state. GAP may itself be regulated by phospholipids and by phosphorylation on a tyrosine residue by growth factor receptors (PDGF-R, EGF-R). The neurofibromatosis type 1 gene (NF1) codes for a protein homologous to GAP. GAP has both SH2 and SH3domains. Another example is sar-1 (from yeast).

Dictionary of molecular biology. 2004.

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