glutathione


glutathione
The tripeptide g -glutamylcysteinylglycine. It contains an unusual peptide linkage between the g -carboxyl group of the glutamate side chain and the amine group of cysteine. The concentration of glutathione in animal cells is around 5mM and its sulphydryl group is kept largely in the reduced state. This allows it to act as a sulphydryl buffer, reducing any disulphide bonds formed within cytoplasmic proteins to cysteines. Hence, few, if any, cytoplasmic proteins contain disulphide bonds. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids and participates in leukotriene synthesis.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Glutathione — Glutathione[1] …   Wikipedia

  • glutathione — [glo͞ot΄ə thī′ōn΄] n. a polypeptide, C10H17O6N3S, containing cysteine, glutamic acid, and glycine and involved, as an antioxidant and coenzyme, in the normal biochemical reactions occurring in plant and animal tissues …   English World dictionary

  • glutathione — A tripeptide of glycine, l cysteine, and l glutamate, with l glutamate having an isopeptide bond with the amino moiety of l cysteine. G. has a wide variety of roles in a cell; it is the most prevalent non protein thiol. G. disulfide (GSSG)… …   Medical dictionary

  • glutathione — n. a peptide containing the amino acids glutamic acid, cysteine, and glycine. It functions as a coenzyme in several oxidation reduction reactions. Glutathione serves as an antioxidant: it reacts with potentially harmful oxidizing agents and is… …   The new mediacal dictionary

  • glutathione — /glooh teuh thuy ohn/, n. Biochem. a crystalline, water soluble peptide of glutamic acid, cysteine, and glycine, C10H17N3O6S, found in blood and in animal and plant tissues, and important in tissue oxidations and in the activation of some enzymes …   Universalium

  • glutathione — noun Etymology: International Scientific Vocabulary gluta (from glutamic acid) + thi + one Date: 1921 a peptide C10H17N3O6S that contains one amino acid residue each of glutamic acid, cysteine, and glycine, that occurs widely in plant and animal… …   New Collegiate Dictionary

  • Glutathione — Glutathion Glutathion Fo …   Wikipédia en Français

  • glutathione — noun A tripeptide formed from glutamic acid, cysteine and glycine, that is active in many biological redox reactions …   Wiktionary

  • glutathione — n. chemical compound found in plants and animals …   English contemporary dictionary

  • glutathione — glu·ta·thi·one …   English syllables


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