formyl peptides


formyl peptides
Informal term for small peptides with a formylated N-terminal methionine and usually a hydrophobic amino acid at the carboxy-terminal end (fMetLeuPhe is the most commonly used). These peptides stimulate the motor and secretory activities of leucocytes, particularly neutrophils and monocytes, that have a specific receptor (about 60 kD) of high affinity (Kd approximately 10-8 M). Leucocytes show chemotaxis towards formyl peptides but the term chemotactic peptides understates the range of activities the molecules will trigger. Thought to be synthetic analogues of bacterial signal sequences - though this is unproven. The leucocytes of many animals (eg. pig, cow, chicken) do not respond.

Dictionary of molecular biology. 2004.

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  • Formyl peptide receptor 1 — Formyl peptide receptor 1, also known as FPR1, is a human gene.cite web | title = Entrez Gene: FPR1 formyl peptide receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2357| accessdate = ] PBB Summary …   Wikipedia

  • Formyl peptide receptor — protein Name=formyl peptide receptor 1 caption= width= HGNCid=3826 Symbol=FPR1 AltSymbols= EntrezGene=2357 OMIM=136537 RefSeq=NM 002029 UniProt=P21462 PDB= ECnumber= Chromosome=19 Arm=q Band=13.41 LocusSupplementaryData=protein Name = formyl… …   Wikipedia

  • Formyl peptide receptor-like 1 — Formyl peptide receptor like 1, also known as FPRL1, is a human gene. [cite web | title = Entrez Gene: FPRL1 Formyl peptide receptor like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2358| accessdate …   Wikipedia

  • f-met-leu-phe — (= formyl methionyl leucyl phenylalanine; fMLP) See formyl peptides …   Dictionary of molecular biology

  • Chemotaxis — is the phenomenon in which somatic cells, bacteria, and other single cell or multicellular organisms direct their movements according to certain chemicals in their environment. This is important for bacteria to find food (for example, glucose) by …   Wikipedia

  • Federica Sallusto — (born November 27, 1961) is an Italian biologist. She was born in Naples, Italy. After high school, she studied in the Faculty of Biology at the University of La Sapienza in Rome where she took the degree with honors.She is currently group leader …   Wikipedia

  • Chemoattractant — Inorganic or organic substances possessing chemotaxis inducer effect in motile cells. Effect of chemoattractants is elicited via described or hypothetic chemotaxis receptors, the chemoattractant moiety of a ligand is target cell specific and… …   Wikipedia

  • GUSB — Glucuronidase, beta, also known as GUSB, is a human gene.cite web | title = Entrez Gene: GUSB glucuronidase, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2990| accessdate = ] PBB Summary section… …   Wikipedia

  • DMSO — Dimethyl sulphoxide. Much used as a solvent for substances that do not dissolve easily in water and that are to be applied to cells (for example cytochalasin B, formyl peptides), also as a cryoprotectant when freezing cells for storage. It is… …   Dictionary of molecular biology

  • fMLP — See formyl peptides …   Dictionary of molecular biology


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