(= tetrahydrofolate)
Molecule that acts as a carrier of one-carbon units in intermediary metabolism. It contains residues of p -aminobenzoate, glutamate, and a substituted pteridine. The latter cannot be synthesized by mammals, which must obtain tetrahydrofolate as a vitamin or from intestinal microorganisms. One-carbon units are carried at three different levels of oxidation, as methyl-, methylene- or formimino- groups. Important biosyntheses dependent on tetrahydrofolate include those of methionine, thymine and purines. Analogues of dihydrofolate, such as aminopterin and methotrexate block the action of tetrahydrofolate by inhibiting its regeneration from dihydrofolate.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

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  • folate — folic acid ► NOUN ▪ a vitamin of the B complex found especially in leafy green vegetables, liver, and kidney. DERIVATIVES folate noun. ORIGIN from Latin folium leaf …   English terms dictionary

  • folate — noun Date: 1951 folic acid …   New Collegiate Dictionary

  • folate — fo·late (fōʹlāt ) n. 1. A salt or ester of folic acid. 2. See folic acid.   [folic acid + ate2.] * * * …   Universalium

  • folate — noun A salt or ester of folic acid, especially one present in the vitamin B complex …   Wiktionary

  • folate — [ fəʊleɪt] noun Biochemistry a salt or ester of folic acid …   English new terms dictionary

  • folate — fo·late …   English syllables

  • folate — /ˈfoʊleɪt/ (say fohlayt) noun a vitamin found in many fruits and vegetables in the form of folic acid, which is essential for the formation of red blood cells. {fol(ic acid) + ate2} …   Australian English dictionary

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