aldose reductase
Enzyme that mediates conversion of glucose to sorbitol and the rate-limiting enzyme in the polyol pathway. Altered activity of aldose reductase is thought to play a part in the alterations in the vasculature seen as a complication of diabetes.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Aldose reductase — (or aldehyde reductase) is an enzyme in carbohydrate metabolism that converts an aldose to a sugar alcohol, using NADPH as the reducing agent.The enzyme can be inhibited by aldose reductase inhibitors.ReactionsSpecific reactions catalyzed by this …   Wikipedia

  • aldose reductase — aldose reductase. См. альдоредуктаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • aldose reductase — al·dose re·duc·tase (alґdōs re dukґtās) aldehyde reductase …   Medical dictionary

  • Aldose reductase inhibitor — Aldose reductase inhibitors are a class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes. MechanismTheir target, aldose reductase, is an enzyme that is normally present in many other parts of the body, and… …   Wikipedia

  • Aldose reductase inhibitor — A class of drugs used to prevent eye and nerve damage in diabetes. Aldose reductase is an enzyme that is normally present in the eye and in many other parts of the body. It helps change glucose into a sugar alcohol called sorbitol. Too much… …   Medical dictionary

  • aldose reductase inhibitor — (Pharmacology) class of drugs which inhibit activity of the aldose reductase enzyme (currently being studied as a possible treatment for eye and nerve damage in diabetics) …   English contemporary dictionary

  • Aldose-6-phosphate reductase (NADPH) — In enzymology, an aldose 6 phosphate reductase (NADPH) (EC number|1.1.1.200) is an enzyme that catalyzes the chemical reaction:D sorbitol 6 phosphate + NADP+ ightleftharpoons D glucose 6 phosphate + NADPH + H+Thus, the two substrates of this… …   Wikipedia

  • aldose — A monosaccharide potentially containing the characteristic group of the aldehydes, CHO; a polyhydroxyaldehyde. a. mutarotase SYN: a. 1 epimerase. a. reductase polyol dehydrogenase (NADP+); an oxidoreductase that reversibly converts aldoses to… …   Medical dictionary

  • Dihydrofolate reductase inhibitor — A dihydrofolate reductase inhibitor is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate. Since folate is needed by rapidly dividing cells to make thymine, this effect may be used to therapeutic… …   Wikipedia

  • aldehyde reductase — al·de·hyde re·duc·tase (alґdə hīd re dukґtās) [EC 1.1.1.21] an enzyme of the oxidoreductase class that catalyzes the reduction of aldoses to form alditols, using NADPH as an electron donor. In galactosemia due to galactokinase… …   Medical dictionary

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