farnesylation
The farnesyl group is the linear grouping of three isoprene units. It is specifically attached to proteins that contain the C-terminal motif CAAX by cleavage and addition to the SH group of C; the free carboxylate group is also methylated. Believed to act as a membrane attachment device. See also polyisoprenylation.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • farnesylation — noun The act or process of farnesylating …   Wiktionary

  • Farnesyltransferase inhibitor — The farnesyltransferase inhibitors (FTIs) are a class of experimental cancer drugs that target protein farnesyltransferase with the downstream effect of preventing the proper functioning of the Ras (protein), which is commonly abnormally active… …   Wikipedia

  • Laminopathy — Normal nuclear lamina (a and b) and mutant nuclear lamina (c and d) from a patient with HGPS, visualized by immunofluorescence note the irregular and bumpy shape of the laminopathic nuclei[1] Laminopathies are a group of rare genetic disorders… …   Wikipedia

  • Farnesyltransferase — is one of the three enzymes in the prenyltransferase group. Farnesyltransferase (FTase) adds a 15 carbon isoprenoid called a farnesyl group to proteins bearing a CaaX motif: a four amino acid sequence at the carboxyl terminus of a protein.… …   Wikipedia

  • RHEB — Ras homolog enriched in brain, also known as RHEB, is a human gene. PBB Summary section title = summary text = This gene is a member of the small GTPase superfamily and encodes a lipid anchored, cell membrane protein with five repeats of the RAS… …   Wikipedia

  • CENPF — Centromere protein F, 350/400ka (mitosin), also known as CENPF, is a human gene.cite web | title = Entrez Gene: CENPF centromere protein F, 350/400ka (mitosin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Posttranslational modification — (PTM) is the chemical modification of a protein after its translation. It is one of the later steps in protein biosynthesis for many proteins.A protein (also called a polypeptide) is a chain of amino acids. During protein synthesis, 20 different… …   Wikipedia

  • Progeria — Infobox Disease Name = Progeria Caption = DiseasesDB = 10704 ICD10 = ICD10|E|34|8|e|20 ICD9 = ICD9|259.8 ICDO = OMIM = 176670 MedlinePlus = eMedicineSubj = derm eMedicineTopic = 731 MeshID = D011371 Progeria is a condition of early aging [Stedman …   Wikipedia

  • Prenylation — or isoprenylation or lipidation is the addition of hydrophobic molecules to a protein. It is usually assumed that prenyl groups facilitate attachment to cell membranes, similar to lipid anchor like the GPI anchor, though direct evidence is… …   Wikipedia

  • Geranylgeranyltransferase type 1 — protein Name=protein geranylgeranyltransferase type I, beta subunit caption= width= HGNCid=8895 Symbol=PGGT1B AltSymbols= EntrezGene=5229 OMIM=602031 RefSeq=NM 005023 UniProt=P53609 PDB=1S64 ECnumber=2.5.1.59 Chromosome=5 Arm=q Band=23.1… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”