extrinsic pathway


extrinsic pathway
Initiation of blood clotting as a result of factors released from damaged tissue, as opposed to contact with a foreign surface (the intrinsic pathway). Tissue thromboplastin (Factor III) in conjunction with Factor VII (proconvertin) will activate Factor X that, once activated, converts prothrombin to thrombin.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • extrinsic pathway of coagulation — the mechanism that produces fibrin following tissue injury, beginning with formation of an activated complex between tissue factor and activated factor VII and leading to activation of factor X, which induces the reactions of the common pathway… …   Medical dictionary

  • Tissue factor pathway inhibitor — (or TFPI) is a single chain polypeptide which can reversibly inhibit Factor Xa (Xa). While Xa is inhibited, the Xa TFPI complex can subsequently also inhibit the FVIIa TF complex.TFPI contributes significantly to the inhibition of Xa in vivo,… …   Wikipedia

  • intrinsic pathway — See extrinsic pathway …   Dictionary of molecular biology

  • intrinsic pathway of coagulation — a sequence of reactions leading to fibrin formation, beginning with the contact activation of factor XII, followed by the sequential activation of factors XI and IX, and resulting in the activation of factor X, which in activated form initiates… …   Medical dictionary

  • common pathway of coagulation — the steps in the mechanism of coagulation from the activation of factor X through the conversion of fibrinogen to fibrin. See illustration. See also intrinsic p. of coagulation and extrinsic p. of coagulation …   Medical dictionary

  • bleeding and blood clotting — ▪ disease Introduction       escape of blood from blood vessels into surrounding tissue and the process of coagulation through the action of platelets. Significance of hemostasis       The evolution of high pressure blood circulation in… …   Universalium

  • Coagulation — This article is about blood clotting. For other meanings see Coagulation (disambiguation). Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel,… …   Wikipedia

  • Tissue factor — Coagulation factor III (thromboplastin, tissue factor) PDB rendering based on 1ahw …   Wikipedia

  • nervous system, human — ▪ anatomy Introduction       system that conducts stimuli from sensory receptors to the brain and spinal cord and that conducts impulses back to other parts of the body. As with other higher vertebrates, the human nervous system has two main… …   Universalium

  • Factor X — For other uses, see Factor X (disambiguation). Coagulation factor X PDB rendering based on 1c5m …   Wikipedia


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